GPCPD1

Protein identityUniProt · HPA

UniProt accession

Q9NPB8

Gene

GPCPD1

Ensembl

ENSG00000125772

Chromosome

20

Canonical length

672 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable glycerophosphocholine phosphodiesterase activity. Predicted to be involved in glycerophospholipid catabolic process. Predicted to act upstream of or within skeletal muscle tissue development. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>Q9NPB8|GPCPD1
     1  MTPSQVAFEI RGTLLPGEVF AICGSCDALG NWNPQNAVAL LPENDTGESM LWKATIVLSR
    61  GVSVQYRYFK GYFLEPKTIG GPCQVIVHKW ETHLQPRSIT PLESEIIIDD GQFGIHNGVE
   121  TLDSGWLTCQ TEIRLRLHYS EKPPVSITKK KLKKSRFRVK LTLEGLEEDD DDRVSPTVLH
   181  KMSNSLEISL ISDNEFKCRH SQPECGYGLQ PDRWTEYSIQ TMEPDNLELI FDFFEEDLSE
   241  HVVQGDALPG HVGTACLLSS TIAESGKSAG ILTLPIMSRN SRKTIGKVRV DYIIIKPLPG
   301  YSCDMKSSFS KYWKPRIPLD VGHRGAGNST TTAQLAKVQE NTIASLRNAA SHGAAFVEFD
   361  VHLSKDFVPV VYHDLTCCLT MKKKFDADPV ELFEIPVKEL TFDQLQLLKL THVTALKSKD
   421  RKESVVQEEN SFSENQPFPS LKMVLESLPE DVGFNIEIKW ICQQRDGMWD GNLSTYFDMN
   481  LFLDIILKTV LENSGKRRIV FSSFDADICT MVRQKQNKYP ILFLTQGKSE IYPELMDLRS
   541  RTTPIAMSFA QFENLLGINV HTEDLLRNPS YIQEAKAKGL VIFCWGDDTN DPENRRKLKE
   601  LGVNGLIYDR IYDWMPEQPN IFQVEQLERL KQELPELKSC LCPTVSRFVP SSLCGESDIH
   661  VDANGIDNVE NA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPCPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

71 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GPCPD1.

Disease | ImmuneIEDB

Conditions an epitope on GPCPD1 was assayed in.

• multiple sclerosis T cell
• berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.2

gnomAD missense Z

2.05

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycerophospholipid catabolic process
• skeletal muscle tissue development

Molecular functions

• glycerophosphocholine phosphodiesterase activity
• starch binding

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Carbohydrate binding module family 20
• Immunoglobulin-like fold
• Carbohydrate-binding-like fold
• PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
• Glycerophosphodiester phosphodiesterase domain
• Starch binding domain
• Glycerophosphoryl diester phosphodiesterase family
• Glycerophosphocholine phosphodiesterase GPCPD1, CBM20 domain
• Glycerophosphodiester Phosphodiesterase
• GPCPD1-like, C2 domain
• GDE1-like C2 domain

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of GPCPD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SLC35D3