PLCXD1
PI-PLC X domain-containing protein 1
Also known as: FLJ11323, PLCX1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NUJ7
- Gene
- PLCXD1
- Ensembl
- ENSG00000182378
- Chromosome
- X
- Canonical length
- 323 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Canonical amino-acid sequenceUniProt
323 residues, UniProt reviewed canonical sequence.
>Q9NUJ7|PLCXD1
1 MGGQVSASNS FSRLHCRNAN EDWMSALCPR LWDVPLHHLS IPGSHDTMTY CLNKKSPISH
61 EESRLLQLLN KALPCITRPV VLKWSVTQAL DVTEQLDAGV RYLDLRIAHM LEGSEKNLHF
121 VHMVYTTALV EDTLTEISEW LERHPREVVI LACRNFEGLS EDLHEYLVAC IKNIFGDMLC
181 PRGEVPTLRQ LWSRGQQVIV SYEDESSLRR HHELWPGVPY WWGNRVKTEA LIRYLETMKS
241 CGRPGGLFVA GINLTENLQY VLAHPSESLE KMTLPNLPRL SAWVREQCPG PGSRCTNIIA
301 GDFIGADGFV SDVIALNQKL LWCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PLCXD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 34 nTPM
- bone marrow: 31 nTPM
- stomach: 25 nTPM
- adipose tissue: 18 nTPM
- spleen: 18 nTPM
- skin: 18 nTPM
Single-cell type
- esophageal apical cells: 179 nCPM
- foveolar cells: 110 nCPM
- megakaryocyte-erythroid progenitors: 87 nCPM
- erythrocyte progenitors: 78 nCPM
- monocytes: 59 nCPM
- syncytiotrophoblasts: 48 nCPM
Immune cell
- non-classical monocyte: 9.1 nTPM
- intermediate monocyte: 6 nTPM
- naive B-cell: 5.6 nTPM
- eosinophil: 5.4 nTPM
- basophil: 3.5 nTPM
- T-reg: 3.2 nTPM
Brain region
- cerebral cortex: 67 nTPM
- cerebellum: 55 nTPM
- white matter: 55 nTPM
- basal ganglia: 47 nTPM
- pons: 37 nTPM
- hippocampal formation: 37 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.53
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PLCXD1 as an antibody target. Whether an autoantibody or antibody against PLCXD1 could matter depends on whether native PLCXD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PLCXD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PLCXD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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