Seroatlas · Human Serome Atlas

PLCXD3

PI-PLC X domain-containing protein 3

Also known as: PLCX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q63HM9
Gene: PLCXD3
Ensembl: ENSG00000182836
Chromosome: 5
Canonical length: 321 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q63HM9|PLCXD3
     1  MASSQGKNEL KLADWMATLP ESMHSIPLTN LAIPGSHDSF SFYIDEASPV GPEQPETVQN
    61  FVSVFGTVAK KLMRKWLATQ TMNFTGQLGA GIRYFDLRIS TKPRDPDNEL YFAHGLFSAK
   121  VNEGLEEINA FLTDHHKEVV FLDFNHFYGM QKYHHEKLVQ MLKDIYGNKM CPAIFAQEVS
   181  LKYLWEKDYQ VLVFYHSPVA LEVPFLWPGQ MMPAPWANTT DPEKLIQFLQ ASITERRKKG
   241  SFFISQVVLT PKASTVVKGV ASGLRETITE RALPAMMQWV RTQKPGESGI NIVTADFVEL
   301  GDFISTVIKL NYVFDEGEAN T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLCXD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 31 nTPM
ovary: 26 nTPM
cerebellum: 21 nTPM
adrenal gland: 12 nTPM
blood vessel: 8.1 nTPM
hypothalamus: 8 nTPM

Single-cell type

cardiomyocytes: 694 nCPM
lactotrophs: 448 nCPM
somatotrophs: 393 nCPM
pancreatic islet cells: 326 nCPM
adrenal medulla cells: 319 nCPM
ovarian stromal cells: 303 nCPM

Immune cell

basophil: 0.5 nTPM
eosinophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 40 nTPM
pons: 38 nTPM
hypothalamus: 29 nTPM
midbrain: 26 nTPM
medulla oblongata: 21 nTPM
spinal cord: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.01
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphoric diester hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLCXD3 as an antibody target. Whether an autoantibody or antibody against PLCXD3 could matter depends on whether native PLCXD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLCXD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLCXD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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