Seroatlas · Human Serome Atlas

GDPD3

Lysophospholipase D GDPD3

Also known as: GDPD3_HUMAN, MGC4171

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L5L3
Gene: GDPD3
Ensembl: ENSG00000102886
Chromosome: 16
Canonical length: 318 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Enables phosphoric diester hydrolase activity. Involved in N-acylethanolamine metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q7L5L3|GDPD3
     1  MSLLLYYALP ALGSYAMLSI FFLRRPHLLH TPRAPTFRIR LGAHRGGSGE LLENTMEAME
    61  NSMAQRSDLL ELDCQLTRDR VVVVSHDENL CRQSGLNRDV GSLDFEDLPL YKEKLEVYFS
   121  PGHFAHGSDR RMVRLEDLFQ RFPRTPMSVE IKGKNEELIR EIAGLVRRYD RNEITIWASE
   181  KSSVMKKCKA ANPEMPLSFT ISRGFWVLLS YYLGLLPFIP IPEKFFFCFL PNIINRTYFP
   241  FSCSCLNQLL AVVSKWLIMR KSLIRHLEER GVQVVFWCLN EESDFEAAFS VGATGVITDY
   301  PTALRHYLDN HGPAARTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDPD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

esophagus: 66 nTPM
vagina: 24 nTPM
colon: 24 nTPM
cervix: 20 nTPM
tonsil: 20 nTPM
stomach: 18 nTPM

Single-cell type

esophageal apical cells: 800 nCPM
late spermatids: 706 nCPM
esophageal suprabasal cells: 123 nCPM
early spermatids: 116 nCPM
extravillous trophoblasts: 115 nCPM
colonocytes: 90 nCPM

Immune cell

neutrophil: 2.5 nTPM
eosinophil: 0.8 nTPM
gdT-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

pons: 5 nTPM
medulla oblongata: 4.3 nTPM
cerebellum: 2.5 nTPM
white matter: 2.4 nTPM
spinal cord: 1.6 nTPM
cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDPD3 as an antibody target. Whether an autoantibody or antibody against GDPD3 could matter depends on whether native GDPD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDPD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GDPD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...