Seroatlas · Human Serome Atlas

GDPD5

Glycerophosphodiester phosphodiesterase domain-containing protein 5

Also known as: GDE2, GDPD5_HUMAN, PP1665

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WTR4
Gene
GDPD5
Ensembl
ENSG00000158555
Chromosome
11
Canonical length
605 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in positive regulation of cell cycle and positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of Notch signaling pathway; neuron differentiation; and regulation of timing of cell differentiation. Predicted to be located in axon; neuronal cell body; and perinuclear endoplasmic reticulum. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

605 residues, UniProt reviewed canonical sequence.

>Q8WTR4|GDPD5
     1  MVRHQPLQYY EPQLCLSCLT GIYGCRWKRY QRSHDDTTPW ERLWFLLLTF TFGLTLTWLY
    61  FWWEVHNDYD EFNWYLYNRM GYWSDWPVPI LVTTAAAFAY IAGLLVLALC HIAVGQQMNL
   121  HWLHKIGLVV ILASTVVAMS AVAQLWEDEW EVLLISLQGT APFLHVGAVA AVTMLSWIVA
   181  GQFARAERTS SQVTILCTFF TVVFALYLAP LTISSPCIME KKDLGPKPAL IGHRGAPMLA
   241  PEHTLMSFRK ALEQKLYGLQ ADITISLDGV PFLMHDTTLR RTTNVEEEFP ELARRPASML
   301  NWTTLQRLNA GQWFLKTDPF WTASSLSPSD HREAQNQSIC SLAELLELAK GNATLLLNLR
   361  DPPREHPYRS SFINVTLEAV LHSGFPQHQV MWLPSRQRPL VRKVAPGFQQ TSGSKEAVAS
   421  LRRGHIQRLN LRYTQVSRQE LRDYASWNLS VNLYTVNAPW LFSLLWCAGV PSVTSDNSHA
   481  LSQVPSPLWI MPPDEYCLMW VTADLVSFTL IVGIFVLQKW RLGGIRSYNP EQIMLSAAVR
   541  RTSRDVSIMK EKLIFSEISD GVEVSDVLSV CSDNSYDTYA NSTATPVGPR GGGSHTKTLI
   601  ERSGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GDPD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 113 nTPM
  • retina: 78 nTPM
  • cerebellum: 56 nTPM
  • testis: 38 nTPM
  • pancreas: 37 nTPM
  • adipose tissue: 29 nTPM

Single-cell type

  • late spermatids: 309 nCPM
  • cone photoreceptor cells: 232 nCPM
  • rod photoreceptor cells: 160 nCPM
  • syncytiotrophoblasts: 135 nCPM
  • tuft cells: 104 nCPM
  • adipocytes: 101 nCPM

Immune cell

  • basophil: 7.7 nTPM
  • T-reg: 2 nTPM
  • MAIT T-cell: 1.7 nTPM
  • memory CD4 T-cell: 1.3 nTPM
  • gdT-cell: 1.2 nTPM
  • memory CD8 T-cell: 0.9 nTPM

Brain region

  • thalamus: 86 nTPM
  • midbrain: 54 nTPM
  • cerebral cortex: 43 nTPM
  • amygdala: 38 nTPM
  • cerebellum: 33 nTPM
  • hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0
gnomAD missense Z
1.7
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GDPD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GDPD5 as an antibody target. Whether an autoantibody or antibody against GDPD5 could matter depends on whether native GDPD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GDPD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GDPD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GDPD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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