Seroatlas · Human Serome Atlas

PLCXD2

PI-PLC X domain-containing protein 2

Also known as: FLJ31579, PLCX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VAA5
Gene: PLCXD2
Ensembl: ENSG00000240891
Chromosome: 3
Canonical length: 305 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q0VAA5|PLCXD2
     1  MLAVRKARRK LRMGTICSPN PSGTKTSSEV CNADWMASLP PHLHNLPLSN LAIPGSHDSF
    61  SYWVDEKSPV GPDQTQAIKR LARISLVKKL MKKWSVTQNL TFREQLEAGI RYFDLRVSSK
   121  PGDADQEIYF IHGLFGIKVW DGLMEIDSFL TQHPQEIIFL DFNHFYAMDE THHKCLVLRI
   181  QEAFGNKLCP ACSVESLTLR TLWEKNCQVL IFYHCPFYKQ YPFLWPGKKI PAPWANTTSV
   241  RKLILFLETT LSERASRGSF HVSQAILTPR VKTIARGLVG GLKNTLVHSN RWNSHGPSLL
   301  SQERS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLCXD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

retina: 14 nTPM
bone marrow: 4.4 nTPM
cerebral cortex: 3.6 nTPM
lymph node: 2.7 nTPM
cerebellum: 2.6 nTPM
duodenum: 2.6 nTPM

Single-cell type

hepatocytes: 160 nCPM
parietal cells: 156 nCPM
cone photoreceptor cells: 60 nCPM
nk-cells: 55 nCPM
rod photoreceptor cells: 54 nCPM
epididymal clear cells: 53 nCPM

Immune cell

plasmacytoid DC: 3.8 nTPM
gdT-cell: 1.8 nTPM
MAIT T-cell: 1.8 nTPM
memory CD8 T-cell: 1.8 nTPM
NK-cell: 1.1 nTPM
memory CD4 T-cell: 0.9 nTPM

Brain region

cerebral cortex: 22 nTPM
midbrain: 14 nTPM
pons: 14 nTPM
thalamus: 12 nTPM
basal ganglia: 11 nTPM
medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphoric diester hydrolase activity

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLCXD2 as an antibody target. Whether an autoantibody or antibody against PLCXD2 could matter depends on whether native PLCXD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLCXD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLCXD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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