GDPD4
Glycerophosphodiester phosphodiesterase domain-containing protein 4
Also known as: GDE6, GDPD4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6W3E5
- Gene
- GDPD4
- Ensembl
- ENSG00000178795
- Chromosome
- 11
- Canonical length
- 623 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable glycerophosphodiester phosphodiesterase activity. Predicted to be involved in lipid metabolic process. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
623 residues, UniProt reviewed canonical sequence.
>Q6W3E5|GDPD4
1 MLLFLWIETS SEYFNFDWVT FLGTGYWFFW SIFILSLARI LTAYSSLLLL LGFLLLWERI
61 ELYLHLCHKI LILLVILLCV ILMFIICKFW KERWLVAGLS MQIFAPYVHL VSITVMVILF
121 WPVAFYVACL EREVRMRRYR MTHSEKKRLK QCNVITRLRG LQVPVGLPFL LILLGLYLMP
181 LGIYSPCIQE KENLGPKPTI FGHRGAPMLG PENTMMSFEK AVEHGAHGLE TDIHLSYDHV
241 PFLMHDFDLK RTTNIGEVQP ESACENPAFF NWDFLSTLNA GKWFVKPELR PFYNMKPLSE
301 ADKERARNQS IPTLADLLTL AEKERKFVIF DLHRPPPKHP LRHTFVRQVV SVILASKIEQ
361 HLIFWLPAHD RQYVRSVAPG FQHVGRLVSI ETLAKNNISI INVDYKKLFP NGLRDYKAAN
421 IHINVYTVNE PWLFSLAWCS RINSVTTDNI GLLSQLDHPH FFMTPKFYVF MWLLADIISV
481 LFIVAIFCFH WRRETEKEKL FETSSTRTDT QSGNLHIAMK PPVRVVEGPW TLAALYPALP
541 KSGKEHQGHF NFAAPSKKLL PIKNAVTPLK PGKHEIQPPM PTVVFELTQA PTRQATSEAT
601 FQTTLPTLKV DKPTMPSIEV PYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GDPD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 3.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.6 nTPM
- retina: 1.4 nTPM
- liver: 0.6 nTPM
- adrenal gland: 0.2 nTPM
- placenta: 0.2 nTPM
- pituitary gland: 0.1 nTPM
Single-cell type
- early primary spermatocytes: 127 nCPM
- undifferentiated spermatogonia: 37 nCPM
- late spermatids: 22 nCPM
- late primary spermatocytes: 20 nCPM
- oocytes: 18 nCPM
- differentiating spermatogonia: 17 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 1.5 nTPM
- hypothalamus: 0.5 nTPM
- pons: 0.5 nTPM
- medulla oblongata: 0.4 nTPM
- white matter: 0.4 nTPM
- cerebral cortex: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.11
- gnomAD pLI
- 0
- gnomAD missense Z
- 0
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GDPD4 as an antibody target. Whether an autoantibody or antibody against GDPD4 could matter depends on whether native GDPD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GDPD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GDPD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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