TRAM/LAG1/CLN8 homology domain

Definition

TLC is a protein domain with at least 5 transmembrane α-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis PMID:11694577, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains PMID:9872981.

16 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (16 proteins: gene, accession, name)

• CERS1
• CERS2
• CERS3
• CERS4
• CERS5
• CERS6
• CLN8
• TLCD1
• TLCD2
• TLCD3A
• TLCD3B
• TLCD4
• TLCD5
• TRAM1
• TRAM1L1
• TRAM2