CERS4
Ceramide synthase 4
Also known as: CERS4_HUMAN, FLJ12089, LASS4, Trh1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9HA82
- Gene
- CERS4
- Ensembl
- ENSG00000090661
- Chromosome
- 19
- Canonical length
- 394 aa
- Protein class
- Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
394 residues, UniProt reviewed canonical sequence.
>Q9HA82|CERS4
1 MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL AMRLAFERFI
61 GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL SLLAAQCGLT LQQTQRWFRR
121 RRNQDRPQLT KKFCEASWRF LFYLSSFVGG LSVLYHESWL WAPVMCWDRY PNQTLKPSLY
181 WWYLLELGFY LSLLIRLPFD VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD
241 SSDYLLEACK MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
301 GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS EEAAAAQEPL
361 QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTATLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CERS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 84 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 84 nTPM
- esophagus: 62 nTPM
- epididymis: 58 nTPM
- liver: 55 nTPM
- salivary gland: 52 nTPM
- thyroid gland: 50 nTPM
Single-cell type
- esophageal apical cells: 283 nCPM
- müller glia: 254 nCPM
- esophageal suprabasal cells: 195 nCPM
- breast lactating cells: 187 nCPM
- respiratory ciliated cells: 179 nCPM
- epididymal principal cells: 175 nCPM
Immune cell
- eosinophil: 28 nTPM
- neutrophil: 23 nTPM
- NK-cell: 23 nTPM
- memory B-cell: 20 nTPM
- naive B-cell: 18 nTPM
- basophil: 13 nTPM
Brain region
- white matter: 96 nTPM
- cerebral cortex: 86 nTPM
- medulla oblongata: 84 nTPM
- basal ganglia: 74 nTPM
- amygdala: 71 nTPM
- pons: 71 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.68
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.75
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CERS4 as an antibody target. Whether an autoantibody or antibody against CERS4 could matter depends on whether native CERS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CERS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CERS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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