Seroatlas · Human Serome Atlas

CERS5

Ceramide synthase 5

Also known as: CERS5_HUMAN, FLJ25304, LASS5, MGC45411, Trh4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5B7
Gene
CERS5
Ensembl
ENSG00000139624
Chromosome
12
Canonical length
392 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Nuclear membrane,Endoplasmic reticulum,Primary cilium

OverviewNCBI Gene

This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q8N5B7|CERS5
     1  MATAAQGPLS LLWGWLWSER FWLPENVSWA DLEGPADGYG YPRGRHILSV FPLAAGIFFV
    61  RLLFERFIAK PCALCIGIED SGPYQAQPNA ILEKVFISIT KYPDKKRLEG LSKQLDWNVR
   121  KIQCWFRHRR NQDKPPTLTK FCESMWRFTF YLCIFCYGIR FLWSSPWFWD IRQCWHNYPF
   181  QPLSSGLYHY YIMELAFYWS LMFSQFTDIK RKDFLIMFVH HLVTIGLISF SYINNMVRVG
   241  TLIMCLHDVS DFLLEAAKLA NYAKYQRLCD TLFVIFSAVF MVTRLGIYPF WILNTTLFES
   301  WEIIGPYASW WLLNGLLLTL QLLHVIWSYL IARIALKALI RGKVSKDDRS DVESSSEEED
   361  VTTCTKSPCD SSSSNGANRV NGHMGGSYWA EE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CERS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 32 nTPM
  • choroid plexus: 27 nTPM
  • kidney: 27 nTPM
  • blood vessel: 26 nTPM
  • cervix: 26 nTPM
  • ovary: 26 nTPM

Single-cell type

  • cardiomyocytes: 188 nCPM
  • extravillous trophoblasts: 127 nCPM
  • retinal ganglion cells: 100 nCPM
  • brain inhibitory neurons: 95 nCPM
  • neutrophils: 89 nCPM
  • other brain neurons: 89 nCPM

Immune cell

  • non-classical monocyte: 56 nTPM
  • eosinophil: 43 nTPM
  • neutrophil: 43 nTPM
  • NK-cell: 40 nTPM
  • intermediate monocyte: 38 nTPM
  • total PBMC: 38 nTPM

Brain region

  • hypothalamus: 16 nTPM
  • cerebellum: 16 nTPM
  • pons: 15 nTPM
  • midbrain: 15 nTPM
  • white matter: 14 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
1.19
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CERS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CERS5 as an antibody target. Whether an autoantibody or antibody against CERS5 could matter depends on whether native CERS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CERS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CERS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CERS5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...