Seroatlas · Human Serome Atlas

TLCD5

TLC domain-containing protein 5

Also known as: MGC17839, TLCD5_HUMAN, TMEM136

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRR5
Gene: TLCD5
Ensembl: ENSG00000181264
Chromosome: 11
Canonical length: 245 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q6ZRR5|TLCD5
     1  MALALCLQVL CSLCGWLSLY ISFCHLNKHR SYEWSCRLVT FTHGVLSIGL SAYIGFIDGP
    61  WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCVYFQSEGA LMLAHHTLSI LGIIMALVLG
   121  ESGTEVNAVL FGSELTNPLL QMRWFLRETG HYHSFTGDVV DFLFVALFTG VRIGVGACLL
   181  FCEMVSPTPK WFVKAGGVAM YAVSWCFMFS IWRFAWRKSI KKYHAWRSRR SEERQLKHNG
   241  HLKIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLCD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

retina: 48 nTPM
adrenal gland: 13 nTPM
choroid plexus: 12 nTPM
basal ganglia: 11 nTPM
spinal cord: 11 nTPM
heart muscle: 11 nTPM

Single-cell type

rod photoreceptor cells: 88 nCPM
cone photoreceptor cells: 54 nCPM
adrenal cortex cells: 45 nCPM
epididymal principal cells: 44 nCPM
sertoli cells: 40 nCPM
astrocytes: 33 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
T-reg: 0.4 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 27 nTPM
basal ganglia: 27 nTPM
white matter: 24 nTPM
cerebellum: 24 nTPM
thalamus: 22 nTPM
medulla oblongata: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0.01
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

TRAM/LAG1/CLN8 homology domain
TLC domain-containing protein 5

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLCD5 as an antibody target. Whether an autoantibody or antibody against TLCD5 could matter depends on whether native TLCD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLCD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLCD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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