Seroatlas · Human Serome Atlas

TRAM1L1

Translocating chain-associated membrane protein 1-like 1

Also known as: MGC26568, TR1L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N609
Gene: TRAM1L1
Ensembl: ENSG00000174599
Chromosome: 4
Canonical length: 369 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q8N609|TRAM1L1
     1  MGLRKKSTKN PPVLSQEFIL QNHADIVSCV GMFFLLGLVF EGTAEASIVF LTLQHSVAVP
    61  AAEEQATGSK SLYYYGVKDL ATVFFYMLVA IIIHATIQEY VLDKINKRMQ FTKAKQNKFN
   121  ESGQFSVFYF FSCIWGTFIL ISENCLSDPT LIWKARPHSM MTFQMKFFYI SQLAYWFHAF
   181  PELYFQKTKK QDIPRQLVYI GLHLFHITGA YLLYLNHLGL LLLVLHYFVE LLSHMCGLFY
   241  FSDEKYQKGI SLWAIVFILG RLVTLIVSVL TVGFHLAGSQ NRNPDALTGN VNVLAAKIAV
   301  LSSSCTIQAY VTWNLITLWL QRWVEDSNIQ ASCMKKKRSR SSKKRTENGV GVETSNRVDC
   361  PPKRKEKSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAM1L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 7.9 nTPM
spinal cord: 7.4 nTPM
kidney: 6.4 nTPM
basal ganglia: 6.3 nTPM
hippocampal formation: 5.9 nTPM
epididymis: 5.7 nTPM

Single-cell type

oligodendrocytes: 15 nCPM
retinal pigment epithelial cells: 13 nCPM
oligodendrocyte progenitor cells: 11 nCPM
epididymal principal cells: 9.1 nCPM
other brain neurons: 7.6 nCPM
decidual stromal cells: 7.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 9.6 nTPM
hypothalamus: 9.1 nTPM
pons: 9 nTPM
basal ganglia: 8.7 nTPM
medulla oblongata: 8.2 nTPM
spinal cord: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.01
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAM1L1 as an antibody target. Whether an autoantibody or antibody against TRAM1L1 could matter depends on whether native TRAM1L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAM1L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAM1L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...