Seroatlas · Human Serome Atlas

TLCD3A

TLC domain-containing protein 3A

Also known as: CT120, FAM57A, FLJ22282, TLC3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBR7
Gene: TLCD3A
Ensembl: ENSG00000167695
Chromosome: 17
Canonical length: 257 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q8TBR7|TLCD3A
     1  MLLTLAGGAL FFPGLFALCT WALRRSQPGW SRTDCVMIST RLVSSVHAVL ATGSGIVIIR
    61  SCDDVITGRH WLAREYVWFL IPYMIYDSYA MYLCEWCRTR DQNRAPSLTL RNFLSRNRLM
   121  ITHHAVILFV LVPVAQRLRG DLGDFFVGCI FTAELSTPFV SLGRVLIQLK QQHTLLYKVN
   181  GILTLATFLS CRILLFPFMY WSYGRQQGLS LLQVPFSIPF YCNVANAFLV APQIYWFCLL
   241  CRKAVRLFDT PQAKKDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLCD3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

skin: 71 nTPM
esophagus: 24 nTPM
stomach: 17 nTPM
vagina: 17 nTPM
urinary bladder: 17 nTPM
choroid plexus: 17 nTPM

Single-cell type

suprabasal keratinocytes: 63 nCPM
basal keratinocytes: 57 nCPM
esophageal suprabasal cells: 48 nCPM
esophageal basal cells: 48 nCPM
early spermatids: 38 nCPM
ocular epithelial cells: 36 nCPM

Immune cell

T-reg: 1.5 nTPM
gdT-cell: 1.2 nTPM
MAIT T-cell: 1.1 nTPM
memory CD8 T-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM
naive CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 19 nTPM
choroid plexus: 19 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 11 nTPM
white matter: 9.4 nTPM
pons: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.26
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLCD3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLCD3A as an antibody target. Whether an autoantibody or antibody against TLCD3A could matter depends on whether native TLCD3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLCD3A is annotated at the cell surface, where native TLCD3A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TLCD3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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