Seroatlas · Human Serome Atlas

TLCD2

TLC domain-containing protein 2

Also known as: TLCD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGC4
Gene
TLCD2
Ensembl
ENSG00000185561
Chromosome
17
Canonical length
264 aa
Protein class
Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>A6NGC4|TLCD2
     1  MAPTGLLVAG ASFLAFRGLH WGLRRLPTPE SAARDRWQWW NLCVSLAHSL LSGTGALLGL
    61  SLYPQMAADP IHGHPRWALV LVAVSVGYFL ADGADLLWNQ TLGKTWDLLC HHLVVVSCLS
   121  TAVLSGHYVG FSMVSLLLEL NSACLHLRKL LLLSRQAPSL AFSVTSWASL ATLALFRLVP
   181  LGWMSLWLFR QHHQVPLALV TLGGIGLVTV GIMSIILGIR ILVNDVLQSR PHPPSPGHEK
   241  TRGTRTRRDN GPVTSNSSTL SLKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
9.7 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 9.7 nTPM
  • retina: 9.7 nTPM
  • adrenal gland: 8.8 nTPM
  • colon: 6.9 nTPM
  • liver: 6.5 nTPM
  • small intestine: 6.5 nTPM

Single-cell type

  • papillary tip epithelial cells: 11 nCPM
  • podocytes: 6.2 nCPM
  • renal collecting duct principal cells: 5.2 nCPM
  • renal connecting tubule cells: 3.9 nCPM
  • renal collecting duct intercalated cells: 3.6 nCPM
  • loop of henle epithelial cells: 3.1 nCPM

Immune cell

  • basophil: 3.3 nTPM
  • neutrophil: 1.5 nTPM
  • eosinophil: 0.4 nTPM
  • naive B-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • NK-cell: 0.3 nTPM

Brain region

  • choroid plexus: 8.2 nTPM
  • white matter: 6.8 nTPM
  • cerebellum: 6.7 nTPM
  • medulla oblongata: 5.9 nTPM
  • cerebral cortex: 5.8 nTPM
  • pons: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
0.01
DepMap dependency class
none

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLCD2 as an antibody target. Whether an autoantibody or antibody against TLCD2 could matter depends on whether native TLCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLCD2 is annotated at the cell surface, where native TLCD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TLCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TLCD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...