Seroatlas · Human Serome Atlas

TLCD1

TLC domain-containing protein 1

Also known as: TLCD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96CP7
Gene: TLCD1
Ensembl: ENSG00000160606
Chromosome: 17
Canonical length: 247 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q96CP7|TLCD1
     1  MPRLLHPALP LLLGATLTFR ALRRALCRLP LPVHVRADPL RTWRWHNLLV SFAHSIVSGI
    61  WALLCVWQTP DMLVEIETAW SLSGYLLVCF SAGYFIHDTV DIVASGQTRA SWEYLVHHVM
   121  AMGAFFSGIF WSSFVGGGVL TLLVEVSNIF LTIRMMMKIS NAQDHLLYRV NKYVNLVMYF
   181  LFRLAPQAYL THFFLRYVNQ RTLGTFLLGI LLMLDVMIII YFSRLLRSDF CPEHVPKKQH
   241  KDKFLTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

kidney: 21 nTPM
skin: 20 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 16 nTPM
amygdala: 16 nTPM
choroid plexus: 15 nTPM

Single-cell type

urothelial cells: 77 nCPM
epididymal basal cells: 65 nCPM
colonocytes: 55 nCPM
enterocytes: 48 nCPM
endometrial glandular cells: 43 nCPM
extravillous trophoblasts: 42 nCPM

Immune cell

plasmacytoid DC: 22 nTPM
basophil: 1.9 nTPM
memory B-cell: 1.4 nTPM
intermediate monocyte: 1.1 nTPM
classical monocyte: 0.9 nTPM
myeloid DC: 0.9 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 14 nTPM
midbrain: 14 nTPM
thalamus: 12 nTPM
hypothalamus: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLCD1 as an antibody target. Whether an autoantibody or antibody against TLCD1 could matter depends on whether native TLCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLCD1 is annotated at the cell surface, where native TLCD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TLCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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