Seroatlas · Human Serome Atlas

CERS6

Ceramide synthase 6

Also known as: CERS6_HUMAN, LASS6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMG9
Gene: CERS6
Ensembl: ENSG00000172292
Chromosome: 2
Canonical length: 384 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>Q6ZMG9|CERS6
     1  MAGILAWFWN ERFWLPHNVT WADLKNTEEA TFPQAEDLYL AFPLAFCIFM VRLIFERFVA
    61  KPCAIALNIQ ANGPQIAPPN AILEKVFTAI TKHPDEKRLE GLSKQLDWDV RSIQRWFRQR
   121  RNQEKPSTLT RFCESMWRFS FYLYVFTYGV RFLKKTPWLW NTRHCWYNYP YQPLTTDLHY
   181  YYILELSFYW SLMFSQFTDI KRKDFGIMFL HHLVSIFLIT FSYVNNMARV GTLVLCLHDS
   241  ADALLEAAKM ANYAKFQKMC DLLFVMFAVV FITTRLGIFP LWVLNTTLFE SWEIVGPYPS
   301  WWVFNLLLLL VQGLNCFWSY LIVKIACKAV SRGKVSKDDR SDIESSSDEE DSEPPGKNPH
   361  TATTTNGTSG TNGYLLTGSC SMDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CERS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

small intestine: 30 nTPM
rectum: 28 nTPM
colon: 27 nTPM
heart muscle: 26 nTPM
thyroid gland: 25 nTPM
duodenum: 24 nTPM

Single-cell type

podocytes: 1,192 nCPM
paneth cells: 824 nCPM
enteric stem cells: 775 nCPM
monocyte progenitors: 600 nCPM
sertoli cells: 599 nCPM
neutrophil progenitors: 575 nCPM

Immune cell

plasmacytoid DC: 5.4 nTPM
classical monocyte: 1 nTPM
naive CD4 T-cell: 0.9 nTPM
myeloid DC: 0.8 nTPM
intermediate monocyte: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM

Brain region

hypothalamus: 40 nTPM
cerebral cortex: 36 nTPM
cerebellum: 34 nTPM
hippocampal formation: 34 nTPM
basal ganglia: 33 nTPM
spinal cord: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.04
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CERS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CERS6 as an antibody target. Whether an autoantibody or antibody against CERS6 could matter depends on whether native CERS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CERS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CERS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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