Seroatlas · Human Serome Atlas

TLCD4

TLC domain-containing protein 4

Also known as: FLJ31842, TLCD4_HUMAN, TMEM56

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MV1
Gene: TLCD4
Ensembl: ENSG00000152078
Chromosome: 1
Canonical length: 263 aa
Protein class: Predicted membrane proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to be involved in lipid homeostasis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q96MV1|TLCD4
     1  MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN SRVVSTCHSL
    61  VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI SDLSIIILYW KVIGDKFFIM
   121  HHCASLYAYY LVLKNGVLAY IGNFRLLAEL SSPFVNQRWF FEALKYPKFS KAIVINGILM
   181  TVVFFIVRIA SMLPHYGFMY SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG
   241  CIKVISHIRQ EKAKNSLQNG KLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLCD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

liver: 122 nTPM
heart muscle: 24 nTPM
bone marrow: 19 nTPM
colon: 13 nTPM
skeletal muscle: 12 nTPM
cerebellum: 9.8 nTPM

Single-cell type

astrocytes: 71 nCPM
bergmann glia: 70 nCPM
brain inhibitory neurons: 40 nCPM
oligodendrocyte progenitor cells: 40 nCPM
oligodendrocytes: 37 nCPM
brain excitatory neurons: 36 nCPM

Immune cell

memory B-cell: 0.7 nTPM
naive B-cell: 0.5 nTPM
neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 57 nTPM
cerebral cortex: 47 nTPM
white matter: 42 nTPM
thalamus: 37 nTPM
amygdala: 35 nTPM
basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.26
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLCD4 as an antibody target. Whether an autoantibody or antibody against TLCD4 could matter depends on whether native TLCD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLCD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLCD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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