APLP1

Protein identityUniProt · HPA

UniProt accession

P51693

Gene

APLP1

Ensembl

ENSG00000105290

Chromosome

19

Canonical length

650 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

650 residues, UniProt reviewed canonical sequence.

>P51693|APLP1
     1  MGPASPAARG LSRRPGQPPL PLLLPLLLLL LRAQPAIGSL AGGSPGAAEA PGSAQVAGLC
    61  GRLTLHRDLR TGRWEPDPQR SRRCLRDPQR VLEYCRQMYP ELQIARVEQA TQAIPMERWC
   121  GGSRSGSCAH PHHQVVPFRC LPGEFVSEAL LVPEGCRFLH QERMDQCESS TRRHQEAQEA
   181  CSSQGLILHG SGMLLPCGSD RFRGVEYVCC PPPGTPDPSG TAVGDPSTRS WPPGSRVEGA
   241  EDEEEEESFP QPVDDYFVEP PQAEEEEETV PPPSSHTLAV VGKVTPTPRP TDGVDIYFGM
   301  PGEISEHEGF LRAKMDLEER RMRQINEVMR EWAMADNQSK NLPKADRQAL NEHFQSILQT
   361  LEEQVSGERQ RLVETHATRV IALINDQRRA ALEGFLAALQ ADPPQAERVL LALRRYLRAE
   421  QKEQRHTLRH YQHVAAVDPE KAQQMRFQVH THLQVIEERV NQSLGLLDQN PHLAQELRPQ
   481  IQELLHSEHL GPSELEAPAP GGSSEDKGGL QPPDSKDDTP MTLPKGSTEQ DAASPEKEKM
   541  NPLEQYERKV NASVPRGFPF HSSEIQRDEL APAGTGVSRE AVSGLLIMGA GGGSLIVLSM
   601  LLLRRKKPYG AISHGVVEVD PMLTLEEQQL RELQRHGYEN PTYRFLEERP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APLP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

1,120 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.44

gnomAD pLI

0.12

gnomAD missense Z

1.21

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ morphogenesis
• apoptotic process
• axonogenesis
• cell adhesion
• cellular response to norepinephrine stimulus
• central nervous system development
• cytosolic mRNA polyadenylation
• endocytosis
• extracellular matrix organization
• forebrain development
• negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
• nervous system development
• regulation of translation

Molecular functions

• alpha-2A adrenergic receptor binding
• alpha-2C adrenergic receptor binding
• heparin binding
• identical protein binding
• transition metal ion binding
• alpha-2B adrenergic receptor binding

Cellular components

• basement membrane
• Golgi apparatus
• nucleoplasm
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Amyloidogenic glycoprotein, extracellular
• Amyloidogenic glycoprotein
• Amyloidogenic glycoprotein, copper-binding
• Amyloidogenic glycoprotein, heparin-binding
• Beta-amyloid precursor protein C-terminal
• Amyloidogenic glycoprotein, copper-binding domain conserved site
• Amyloidogenic glycoprotein, intracellular domain, conserved site
• Amyloidogenic glycoprotein, E2 domain
• E2 domain superfamily
• Amyloidogenic glycoprotein, heparin-binding domain superfamily
• Amyloidogenic glycoprotein, copper-binding domain superfamily
• Amyloid A4 N-terminal heparin-binding
• Beta-amyloid precursor protein C-terminus
• Copper-binding of amyloid precursor, CuBD
• E2 domain of amyloid precursor protein

KeywordsUniProt

• Apoptosis
• Cell adhesion
• Cell membrane
• Copper
• Cytoplasm
• Disulfide bond
• Endocytosis
• Glycoprotein
• Heparin-binding
• Membrane
• Metal-binding
• Neurodegeneration
• Signal
• Transmembrane
• Transmembrane helix
• Zinc

InteractionsUniProt · HPA

Protein binding partners of APLP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPEB1
• APBB3
• DAB1
• TK1
• TSC22D1
• ZNF24