YT521-B-like domain
PF04146
Definition
A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells PMID:16823445. It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing. The rat protein [swissprot:Q9QY02] YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner PMID:10564280. The YTH domain has been identified as part of the PUA superfamily PMID:19191354.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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