Seroatlas · Human Serome Atlas

CRB3

Protein crumbs homolog 3

Also known as: CRUM3_HUMAN, MGC17303

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUF7
Gene: CRB3
Ensembl: ENSG00000130545
Chromosome: 19
Canonical length: 120 aa
Protein class: Predicted membrane proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>Q9BUF7|CRB3
     1  MANPGLGLLL ALGLPFLLAR WGRAWGQIQT TSANENSTVL PSSTSSSSDG NLRPEAITAI
    61  IVVFSLLAAL LLAVGLALLV RKLREKRQTE GTYRPSSEEQ VGARVPPTPN LKLPPEERLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

esophagus: 53 nTPM
pancreas: 43 nTPM
skin: 41 nTPM
duodenum: 35 nTPM
kidney: 32 nTPM
liver: 31 nTPM

Single-cell type

esophageal apical cells: 692 nCPM
esophageal suprabasal cells: 173 nCPM
colonocytes: 132 nCPM
suprabasal keratinocytes: 109 nCPM
ocular epithelial cells: 104 nCPM
epididymal efferent duct absorptive cells: 103 nCPM

Immune cell

naive CD4 T-cell: 9.2 nTPM
memory CD4 T-cell: 4.6 nTPM
naive CD8 T-cell: 3.6 nTPM
T-reg: 3.4 nTPM
memory B-cell: 3.1 nTPM
memory CD8 T-cell: 2.2 nTPM

Brain region

choroid plexus: 14 nTPM
cerebellum: 3.8 nTPM
basal ganglia: 2.7 nTPM
pons: 2.4 nTPM
white matter: 2.3 nTPM
cerebral cortex: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.36
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRB3 as an antibody target. Whether an autoantibody or antibody against CRB3 could matter depends on whether native CRB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRB3 is annotated at the cell surface, where native CRB3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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