Seroatlas · Human Serome Atlas

ZNF460

Zinc finger protein 460

Also known as: HZF8, ZN460_HUMAN, ZNF272

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14592
Gene
ZNF460
Ensembl
ENSG00000197714
Chromosome
19
Canonical length
562 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

Canonical amino-acid sequenceUniProt

562 residues, UniProt reviewed canonical sequence.

>Q14592|ZNF460
     1  MAAAWMAPAQ ESVTFEDVAV TFTQEEWGQL DVTQRALYVE VMLETCGLLV ALGDSTKPET
    61  VEPIPSHLAL PEEVSLQEQL AQGVPRYSYL GQAMDQDGPS EMQEYFLRPG TDPQSEKLHG
   121  KMSLEHEGLA TADGICSMMI QNQVSPEDAL YGFDSYGPVT DSLIHEGENS YKFEEMFNEN
   181  CFLVQHEQIL PRVKPYDCPE CGKAFGKSKH LLQHHIIHTG EKPYKCLECG KDFNRRSHLT
   241  RHQRTHNGDK PFVCSECGRT FNRGSHLTRH QRVHSGEKPF VCNECGKAFT YRSNFVLHNK
   301  SHNEKKPFAC SECGKGFYES TALIQHFIIH TGERPFKCLE CGKAFNCRSH LKQHERIHTG
   361  EKPFVCSQCG KAFTHYSTYV LHERAHTGEK PFECKECGKA FSIRKDLIRH FNIHTGEKPY
   421  ECLQCGKAFT RMSGLTRHQW IHTGEKPYVC IQCGKAFCRT TNLIRHFSIH TGEKPYECVE
   481  CGKAFNRRSP LTRHQRIHTA EKSHEPIQSG NVSCESTDLI QHSIIHTESS PVSAVNMETP
   541  SIAAHSSSLD INGFIVEETL PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF460 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
5.6 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 5.6 nTPM
  • adrenal gland: 4.6 nTPM
  • retina: 2.4 nTPM
  • ovary: 2.2 nTPM
  • adipose tissue: 1.8 nTPM
  • skin: 1.8 nTPM

Single-cell type

  • cardiomyocytes: 94 nCPM
  • epicardial cells: 84 nCPM
  • plasma cells: 55 nCPM
  • medullary thymic epithelial cells: 48 nCPM
  • ocular epithelial cells: 33 nCPM
  • salivary myoepithelial cells: 30 nCPM

Immune cell

  • naive B-cell: 2.2 nTPM
  • neutrophil: 1.3 nTPM
  • naive CD4 T-cell: 1.2 nTPM
  • intermediate monocyte: 1.1 nTPM
  • T-reg: 1.1 nTPM
  • eosinophil: 1 nTPM

Brain region

  • white matter: 99 nTPM
  • pons: 81 nTPM
  • medulla oblongata: 80 nTPM
  • cerebellum: 78 nTPM
  • midbrain: 77 nTPM
  • basal ganglia: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.68
gnomAD missense Z
2.55
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF460 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF460 as an antibody target. Whether an autoantibody or antibody against ZNF460 could matter depends on whether native ZNF460 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF460 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF460 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF460. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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