Seroatlas · Human Serome Atlas

ZNF264

Zinc finger protein 264

Also known as: KIAA0412, ZN264_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43296
Gene: ZNF264
Ensembl: ENSG00000083844
Chromosome: 19
Canonical length: 627 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>O43296|ZNF264
     1  MAAAVLTDRA QVSVTFDDVA VTFTKEEWGQ LDLAQRTLYQ EVMLENCGLL VSLGCPVPKA
    61  ELICHLEHGQ EPWTRKEDLS QDTCPGDKGK PKTTEPTTCE PALSEGISLQ GQVTQGNSVD
   121  SQLGQAEDQD GLSEMQEGHF RPGIDPQEKS PGKMSPECDG LGTADGVCSR IGQEQVSPGD
   181  RVRSHNSCES GKDPMIQEEE NNFKCSECGK VFNKKHLLAG HEKIHSGVKP YECTECGKTF
   241  IKSTHLLQHH MIHTGERPYE CMECGKAFNR KSYLTQHQRI HSGEKPYKCN ECGKAFTHRS
   301  NFVLHNRRHT GEKSFVCTEC GQVFRHRPGF LRHYVVHSGE NPYECLECGK VFKHRSYLMW
   361  HQQTHTGEKP YECSECGKVF LESAALIHHY VIHTGEKPFE CLECGKAFNH RSYLKRHQRI
   421  HTGEKPFVCS ECGKAFTHCS TFILHKRAHT GEKPFECKEC GKAFSNRKDL IRHFSIHTGE
   481  KPYECVECGK AFTRMSGLTR HKRIHSGEKP YECVECGKSF CWSTNLIRHA IIHTGEKPYK
   541  CSECGKAFSR SSSLTQHQRM HTGKNPISVT DVGRPFTSGQ TSVTLRELLL GKDFLNVTTE
   601  ANILPEETSS SASDQPYQRE TPQVSSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF264 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

testis: 9.3 nTPM
retina: 8.1 nTPM
bone marrow: 7.7 nTPM
spleen: 7.7 nTPM
pancreas: 7.4 nTPM
thymus: 7.4 nTPM

Single-cell type

adrenal medulla cells: 64 nCPM
respiratory ciliated cells: 63 nCPM
thyrotrophs: 48 nCPM
fallopian tube ciliated cells: 47 nCPM
somatotrophs: 44 nCPM
endometrial ciliated cells: 44 nCPM

Immune cell

eosinophil: 4.3 nTPM
memory B-cell: 4.2 nTPM
naive CD4 T-cell: 3.4 nTPM
naive CD8 T-cell: 3.2 nTPM
memory CD4 T-cell: 2.7 nTPM
NK-cell: 2.4 nTPM

Brain region

medulla oblongata: 46 nTPM
white matter: 45 nTPM
choroid plexus: 41 nTPM
cerebellum: 38 nTPM
thalamus: 36 nTPM
basal ganglia: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF264 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF264 as an antibody target. Whether an autoantibody or antibody against ZNF264 could matter depends on whether native ZNF264 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF264 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF264 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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