Seroatlas · Human Serome Atlas

TCF7

Transcription factor 7

Also known as: TCF-1, TCF7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36402
Gene
TCF7
Ensembl
ENSG00000081059
Chromosome
5
Canonical length
384 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

384 residues, UniProt reviewed canonical sequence.

>P36402|TCF7
     1  MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE
    61  GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET
   121  VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ
   181  KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS
   241  GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN
   301  QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTGG
   361  KRNAFGTYPE KAAAPAPFLP MTVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
519 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 519 nTPM
  • lymph node: 81 nTPM
  • tonsil: 63 nTPM
  • appendix: 49 nTPM
  • fallopian tube: 41 nTPM
  • epididymis: 37 nTPM

Single-cell type

  • innate lymphoid cells: 204 nCPM
  • epicardial cells: 187 nCPM
  • fallopian tube ciliated cells: 165 nCPM
  • thymocytes: 147 nCPM
  • t-cells: 126 nCPM
  • epididymal basal cells: 95 nCPM

Immune cell

  • naive CD4 T-cell: 98 nTPM
  • naive CD8 T-cell: 62 nTPM
  • memory CD4 T-cell: 50 nTPM
  • NK-cell: 43 nTPM
  • memory CD8 T-cell: 29 nTPM
  • MAIT T-cell: 29 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 8.7 nTPM
  • hippocampal formation: 6.9 nTPM
  • midbrain: 6.2 nTPM
  • white matter: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.01
gnomAD missense Z
0.51
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCF7 as an antibody target. Whether an autoantibody or antibody against TCF7 could matter depends on whether native TCF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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