UTY

Protein identityUniProt · HPA

UniProt accession

O14607

Gene

UTY

Ensembl

ENSG00000183878

Chromosome

Y

Canonical length

1347 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1347 residues, UniProt reviewed canonical sequence.

>O14607|UTY
     1  MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD SRLFGFVRLH
    61  EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ
   121  ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY
   181  KSSLKHFQLA LIDCNPCTLS NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA
   241  TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA
   301  FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE
   361  SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQNGSDN WNGGQSLSHH PVQQVYSLCL
   421  TPQKLQHLEQ LRANRDNLNP AQKHQLEQLE SQFVLMQQMR HKEVAQVRTT GIHNGAITDS
   481  SLPTNSVSNR QPHGALTRVS SVSQPGVRPA CVEKLLSSGA FSAGCIPCGT SKILGSTDTI
   541  LLGSNCIAGS ESNGNVPYLQ QNTHTLPHNH TDLNSSTEEP WRKQLSNSAQ GLHKSQSSCL
   601  SGPNEEQPLF STGSAQYHQA TSTGIKKANE HLTLPSNSVP QGDADSHLSC HTATSGGQQG
   661  IMFTKESKPS KNRSLVPETS RHTGDTSNGC ADVKGLSNHV HQLIADAVSS PNHGDSPNLL
   721  IADNPQLSAL LIGKANGNVG TGTCDKVNNI HPAVHTKTDH SVASSPSSAI STATPSPKST
   781  EQRSINSVTS LNSPHSGLHT VNGEGLGKSQ SSTKVDLPLA SHRSTSQILP SMSVSICPSS
   841  TEVLKACRNP GKNGLSNSCI LLDKCPPPRP PTSPYPPLPK DKLNPPTPSI YLENKRDAFF
   901  PPLHQFCTNP KNPVTVIRGL AGALKLDLGL FSTKTLVEAN NEHMVEVRTQ LLQPADENWD
   961  PTGTKKIWRC ESNRSHTTIA KYAQYQASSF QESLREENEK RTQHKDHSDN ESTSSENSGR
  1021  RRKGPFKTIK FGTNIDLSDN KKWKLQLHEL TKLPAFARVV SAGNLLTHVG HTILGMNTVQ
  1081  LYMKVPGSRT PGHQENNNFC SVNINIGPGD CEWFVVPEDY WGVLNDFCEK NNLNFLMSSW
  1141  WPNLEDLYEA NVPVYRFIQR PGDLVWINAG TVHWVQAVGW CNNIAWNVGP LTACQYKLAV
  1201  ERYEWNKLKS VKSPVPMVHL SWNMARNIKV SDPKLFEMIK YCLLKILKQY QTLREALVAA
  1261  GKEVIWHGRT NDEPAHYCSI CEVEVFNLLF VTNESNTQKT YIVHCHDCAR KTSKSLENFV
  1321  VLEQYKMEDL IQVYDQFTLA LSLSSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

6.5 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UTY.

Disease | ImmuneIEDB

Conditions an epitope on UTY was assayed in.

• rejection of transplanted organs and tissues T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.97

gnomAD missense Z

-0.17

DepMap mean gene effect

0.34

DepMap dependency class

none

OntologyGO

Biological processes

• heart development
• regulation of gene expression

Molecular functions

• chromatin DNA binding
• histone demethylase activity
• histone H3K27me2/H3K27me3 demethylase activity
• metal ion binding
• RNA polymerase II cis-regulatory region sequence-specific DNA binding

Cellular components

• MLL3/4 complex
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• JmjC domain
• Tetratricopeptide-like helical domain superfamily
• Tetratricopeptide repeat
• Lysine-specific demethylase 6, GATA-like domain superfamily
• Lysine-specific demethylase 6A/B-like, GATA-like
• Lysine-specific demethylase 6A/B-like, C-terminal helical domain
• Transcriptional Corepressor and Histone Demethylase
• JmjC domain, hydroxylase
• Tetratricopeptide repeat
• Lysine-specific demethylase 6/UTY, C-terminal helical domain
• KDM6, GATA-like

KeywordsUniProt

• Chromatin regulator
• Dioxygenase
• Iron
• Metal-binding
• Nucleus
• Oxidoreductase
• Phosphoprotein
• Repeat
• TPR repeat
• Zinc

InteractionsUniProt · HPA

Protein binding partners of UTY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TLE1
• TLE2