Seroatlas · Human Serome Atlas

TLE1

Transducin-like enhancer protein 1

Also known as: ESG, ESG1, GRG1, TLE-1, TLE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q04724
Gene: TLE1
Ensembl: ENSG00000196781
Chromosome: 9
Canonical length: 770 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>Q04724|TLE1
     1  MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH
    61  YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN
   121  AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK
   181  DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD
   241  GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK
   301  SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT
   361  PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG
   421  FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT
   481  LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP
   541  DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV
   601  WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI
   661  FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN
   721  LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 85 nTPM
liver: 78 nTPM
cervix: 58 nTPM
pancreas: 57 nTPM
amygdala: 49 nTPM
blood vessel: 48 nTPM

Single-cell type

endometrial glandular cells: 1,133 nCPM
endometrial luminal cells: 576 nCPM
innate lymphoid cells: 492 nCPM
salivary acinar cells: 318 nCPM
breast lactating cells: 260 nCPM
b-cells: 258 nCPM

Immune cell

basophil: 8.4 nTPM
memory B-cell: 6.6 nTPM
naive B-cell: 5.8 nTPM
eosinophil: 4.6 nTPM
NK-cell: 4.3 nTPM
MAIT T-cell: 2.9 nTPM

Brain region

hippocampal formation: 77 nTPM
amygdala: 67 nTPM
cerebral cortex: 66 nTPM
midbrain: 61 nTPM
basal ganglia: 58 nTPM
thalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 2.74
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE1 as an antibody target. Whether an autoantibody or antibody against TLE1 could matter depends on whether native TLE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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