USP17L2

Protein identityUniProt · HPA

UniProt accession

Q6R6M4

Gene

USP17L2

Ensembl

ENSG00000223443

Chromosome

8

Canonical length

530 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables cysteine-type deubiquitinase activity. Involved in several processes, including CAAX-box protein processing; protein deubiquitination; and regulation of defense response. Located in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q6R6M4|USP17L2
     1  MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSEARVD LCDDLAPVAR
    61  QLAPRKKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TPPLANYMLS REHSQTCQRP
   121  KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH
   181  KQVDHHSKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL
   241  VKPEELNGEN AYHCGLCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK LAKNVQYPEC
   301  LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGHYFSYVK AQEGQWYKMD DAKVTACSIT
   361  SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RRATQGELKR DHPCLQAPEL
   421  DERLVERATQ ESTLDHWKFP QEQNKTKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP
   481  EQQSSLLNLS STTRTDQESV NTGTLASLQG RTRRSKGKNK HSKRALLVCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP17L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

0.2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

-5.84

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• CAAX-box protein processing
• MAPK cascade
• negative regulation of GTPase activity
• negative regulation of protein processing
• negative regulation of protein targeting to membrane
• positive regulation of GTPase activity
• positive regulation of MDA-5 signaling pathway
• positive regulation of RIG-I signaling pathway
• protein deubiquitination
• protein K48-linked deubiquitination
• protein K63-linked deubiquitination
• regulation of apoptotic process
• regulation of cell migration
• regulation of cell population proliferation
• regulation of defense response to virus by host
• regulation of protein stability
• regulation of ruffle assembly
• regulation of G2/MI transition of meiotic cell cycle

Molecular functions

• cysteine-type deubiquitinase activity

Cellular components

• cytosol
• endoplasmic reticulum membrane
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Peptidase C19, ubiquitin carboxyl-terminal hydrolase
• Ubiquitin specific protease, conserved site
• Ubiquitin specific protease UPS, catalytic domain
• Papain-like cysteine peptidase superfamily
• Ubiquitin carboxyl-terminal hydrolases
• Ubiquitin carboxyl-terminal hydrolase

KeywordsUniProt

• Apoptosis
• Cell cycle
• Endoplasmic reticulum
• Hydrolase
• Nucleus
• Protease
• Thiol protease
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of USP17L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SUDS3