MAP3K2

Protein identityUniProt · HPA

UniProt accession

Q9Y2U5

Gene

MAP3K2

Ensembl

ENSG00000169967

Chromosome

2

Canonical length

619 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>Q9Y2U5|MAP3K2
     1  MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKSSSPKK QNDVRVKFEH RGEKRILQFP
    61  RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV
   121  INGSTQATNL EPLPSLEDLD NTVFGAERKK RLSIIGPTSR DRSSPPPGYI PDELHQVARN
   181  GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY
   241  PDNHQEFSDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSLRSPVS
   301  FSPTDHSLST SSGSSIFTPE YDDSRIRRRG SDIDNPTLTV MDISPPSRSP RAPTNWRLGK
   361  LLGQGAFGRV YLCYDVDTGR ELAVKQVQFD PDSPETSKEV NALECEIQLL KNLLHERIVQ
   421  YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV
   481  HRDIKGANIL RDSTGNVKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR
   541  KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE
   601  AKLRPSADEL LRHMFVHYH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP3K2.

Disease | ImmuneIEDB

Conditions an epitope on MAP3K2 was assayed in.

• gastrointestinal system cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.09

gnomAD pLI

1

gnomAD missense Z

2.31

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to mechanical stimulus
• intracellular signal transduction

Molecular functions

• ATP binding
• MAP kinase kinase kinase activity
• metal ion binding
• protein kinase activity
• protein kinase binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm
• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• PB1 domain
• Protein kinase domain
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain
• PB1-like domain
• Protein kinase domain
• PB1 domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MAP3K2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PKN2
• STK38
• MAPKAP1
• MAP2K5
• SFN
• STUB1
• YWHAB
• YWHAE
• YWHAG
• YWHAZ