PEBP1

Protein identityUniProt · HPA

UniProt accession

P30086

Gene

PEBP1

Ensembl

ENSG00000089220

Chromosome

12

Canonical length

187 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

187 residues, UniProt reviewed canonical sequence.

>P30086|PEBP1
     1  MPVDLSKWSG PLSLQEVDEQ PQHPLHVTYA GAAVDELGKV LTPTQVKNRP TSISWDGLDS
    61  GKLYTLVLTD PDAPSRKDPK YREWHHFLVV NMKGNDISSG TVLSDYVGSG PPKGTGLHRY
   121  VWLVYEQDRP LKCDEPILSN RSGDHRGKFK VASFRKKYEL RAPVAGTCYQ AEWDDYVPKL
   181  YEQLSGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PEBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

2,061 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.89

gnomAD pLI

0.09

gnomAD missense Z

0.94

DepMap mean gene effect

-0.16

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of MAPK cascade

Molecular functions

• ATP binding
• enzyme binding
• phosphatidylethanolamine binding
• protein kinase binding
• RNA binding
• serine-type endopeptidase inhibitor activity

Cellular components

• cytosol
• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Phosphatidylethanolamine-binding, conserved site
• Phosphatidylethanolamine-binding protein
• Phosphatidylethanolamine-binding protein, eukaryotic
• PEBP-like superfamily
• Phosphatidylethanolamine-binding protein

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Disulfide bond
• Lipid-binding
• Nucleotide-binding
• Phosphoprotein
• Protease inhibitor
• Serine protease inhibitor

InteractionsUniProt · HPA

Protein binding partners of PEBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ALOX15
• RAF1
• STK38