Seroatlas · Human Serome Atlas

MOB2

MOB kinase activator 2

Also known as: HCCA2, MOB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q70IA6
Gene: MOB2
Ensembl: ENSG00000182208
Chromosome: 11
Canonical length: 237 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q70IA6|MOB2
     1  MDWLMGKSKA KPNGKKPAAE ERKAYLEPEH TKARITDFQF KELVVLPREI DLNEWLASNT
    61  TTFFHHINLQ YSTISEFCTG ETCQTMAVCN TQYYWYDERG KKVKCTAPQY VDFVMSSVQK
   121  LVTDEDVFPT KYGREFPSSF ESLVRKICRH LFHVLAHIYW AHFKETLALE LHGHLNTLYV
   181  HFILFAREFN LLDPKETAIM DDLTEVLCSG AGGVHSGGSG DGAGSGGPGA QNHVKER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 79 nTPM
colon: 68 nTPM
urinary bladder: 49 nTPM
skin: 46 nTPM
skeletal muscle: 40 nTPM
heart muscle: 34 nTPM

Single-cell type

platelets: 357 nCPM
esophageal apical cells: 265 nCPM
vascular smooth muscle cells: 157 nCPM
smooth muscle cells: 141 nCPM
esophageal suprabasal cells: 84 nCPM
suprabasal keratinocytes: 77 nCPM

Immune cell

T-reg: 14 nTPM
gdT-cell: 12 nTPM
memory CD4 T-cell: 12 nTPM
non-classical monocyte: 11 nTPM
memory CD8 T-cell: 11 nTPM
MAIT T-cell: 10 nTPM

Brain region

medulla oblongata: 18 nTPM
thalamus: 18 nTPM
cerebellum: 16 nTPM
midbrain: 16 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0.05
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MOB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MOB2 as an antibody target. Whether an autoantibody or antibody against MOB2 could matter depends on whether native MOB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MOB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MOB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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