Seroatlas · Human Serome Atlas

TAOK3

Serine/threonine-protein kinase TAO3

Also known as: DPK, JIK, MAP3K18, TAOK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2K8
Gene: TAOK3
Ensembl: ENSG00000135090
Chromosome: 12
Canonical length: 898 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

898 residues, UniProt reviewed canonical sequence.

>Q9H2K8|TAOK3
     1  MRKGVLKDPE IADLFYKDDP EELFIGLHEI GHGSFGAVYF ATNAHTSEVV AIKKMSYSGK
    61  QTHEKWQDIL KEVKFLRQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ
   121  EVEIAAITHG ALHGLAYLHS HALIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG
   181  TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT
   241  LQSNEWTDSF RRFVDYCLQK IPQERPTSAE LLRHDFVRRD RPLRVLIDLI QRTKDAVREL
   301  DNLQYRKMKK ILFQETRNGP LNESQEDEED SEHGTSLNRE MDSLGSNHSI PSMSVSTGSQ
   361  SSSVNSMQEV MDESSSELVM MHDDESTINS SSSVVHKKDH VFIRDEAGHG DPRPEPRPTQ
   421  SVQSQALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN
   481  KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVAIIE KEAKVAAADE KKFQQQILAQ
   541  QKKDLTTFLE SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL
   601  LTQQRLYYDK NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE
   661  YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK
   721  KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KTILKTLKDE QTRKLAILAE QYEQSINEMM
   781  ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA
   841  HLEQKIEEEL AALQKERSER IKNLLERQER EIETFDMESL RMGFGNLVTL DFPKEDYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAOK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

retina: 45 nTPM
bone marrow: 40 nTPM
cerebellum: 35 nTPM
lymph node: 32 nTPM
tonsil: 31 nTPM
thymus: 30 nTPM

Single-cell type

neutrophils: 1,448 nCPM
monocytes: 1,082 nCPM
hematopoietic stem cells: 1,069 nCPM
rod photoreceptor cells: 1,061 nCPM
neutrophil progenitors: 999 nCPM
cone photoreceptor cells: 710 nCPM

Immune cell

basophil: 122 nTPM
non-classical monocyte: 96 nTPM
eosinophil: 92 nTPM
NK-cell: 87 nTPM
neutrophil: 87 nTPM
gdT-cell: 61 nTPM

Brain region

hypothalamus: 72 nTPM
white matter: 72 nTPM
cerebral cortex: 65 nTPM
cerebellum: 62 nTPM
thalamus: 61 nTPM
midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 3.03
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAOK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAOK3 as an antibody target. Whether an autoantibody or antibody against TAOK3 could matter depends on whether native TAOK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAOK3 is annotated at the cell surface, where native TAOK3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAOK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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