PWI domain
IPR002483
Definition
The PWI domain, named after a highly conserved PWI tri-peptide located within its N-terminal region, is a ~80 amino acid module, which is found either at the N terminus or at the C terminus of eukaryotic proteins involved in pre-mRNA processing PMID:10322432. It is generally found in association with other domains such as RRM and RS. The PWI domain is a RNA/DNA-binding domain that has an equal preference for single- and double-stranded nucleic acids and is likely to have multiple important functions in pre-mRNA processing PMID:12600940. Proteins containing this domain include the SR-related nuclear matrix protein of 160kDa (SRm160) splicing and 3'-end cleavage-stimulatory factor, and the mammalian splicing factor PRP3. This domain is also present in Rmn1 from S.pombe, a component of a MTREC submodule, which promotes degradation of meiotic mRNAs and regulatory ncRNAs, and is the major nuclear exosome targeting complex for cryptic unstable transcripts (CUTs) and unspliced pre-mRNAs PMID:25989903. Rmn1 homologues from human RBM26/27 may be involved in turnover of nuclear polyadenylated RNA and are important for PAXT-mediated nuclear RNA decay PMID:31950173. The PWI domain is a soluble, globular and independently folded domain which consists of a four-helix bundle, with structured N- and C-terminal elements PMID:12600940.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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