Seroatlas · Human Serome Atlas

SLC4A7

Sodium bicarbonate cotransporter 3

Also known as: NBC3, S4A7_HUMAN, SBC2, SLC4A6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6M7
Gene
SLC4A7
Ensembl
ENSG00000033867
Chromosome
3
Canonical length
1214 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Focal adhesion sites,Cytosol

OverviewNCBI Gene

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

1214 residues, UniProt reviewed canonical sequence.

>Q9Y6M7|SLC4A7
     1  MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP FSKESRRRHR
    61  HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT EDDDEEHIPH DLFTEMDELC
   121  YRDGEEYEWK ETARWLKFEE DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA
   181  STLDEIADMV LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK
   241  HSDPHLLERN GEGLSASRHS LRTGLSASNL SLRGESPLSL LLGHLLPSSR AGTPAGSRCT
   301  TPVPTPQNSP PSSPSISRLT SRSSQESQRQ APELLVSPAS DDIPTVVIHP PEEDLEAALK
   361  GEEQKNEENV DLTPGILASP QSAPGNLDNS KSGEIKGNGS GGSRENSTVD FSKVDMNFMR
   421  KIPTGAEASN VLVGEVDFLE RPIIAFVRLA PAVLLTGLTE VPVPTRFLFL LLGPAGKAPQ
   481  YHEIGRSIAT LMTDEIFHDV AYKAKDRNDL LSGIDEFLDQ VTVLPPGEWD PSIRIEPPKS
   541  VPSQEKRKIP VFHNGSTPTL GETPKEAAHH AGPELQRTGR LFGGLILDIK RKAPFFLSDF
   601  KDALSLQCLA SILFLYCACM SPVITFGGLL GEATEGRISA IESLFGASLT GIAYSLFAGQ
   661  PLTILGSTGP VLVFEKILYK FCRDYQLSYL SLRTSIGLWT SFLCIVLVAT DASSLVCYIT
   721  RFTEEAFAAL ICIIFIYEAL EKLFDLGETY AFNMHNNLDK LTSYSCVCTE PPNPSNETLA
   781  QWKKDNITAH NISWRNLTVS ECKKLRGVFL GSACGHHGPY IPDVLFWCVI LFFTTFFLSS
   841  FLKQFKTKRY FPTKVRSTIS DFAVFLTIVI MVTIDYLVGV PSPKLHVPEK FEPTHPERGW
   901  IISPLGDNPW WTLLIAAIPA LLCTILIFMD QQITAVIINR KEHKLKKGAG YHLDLLMVGV
   961  MLGVCSVMGL PWFVAATVLS ISHVNSLKVE SECSAPGEQP KFLGIREQRV TGLMIFILMG
  1021  LSVFMTSVLK FIPMPVLYGV FLYMGVSSLK GIQLFDRIKL FGMPAKHQPD LIYLRYVPLW
  1081  KVHIFTVIQL TCLVLLWVIK VSAAAVVFPM MVLALVFVRK LMDLCFTKRE LSWLDDLMPE
  1141  SKKKKEDDKK KKEKEEAERM LQDDDDTVHL PFEGGSLLQI PVKALKYSPD KPVSVKISFE
  1201  DEPRKKYVDA ETSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC4A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • retina: 68 nTPM
  • duodenum: 54 nTPM
  • tongue: 25 nTPM
  • breast: 18 nTPM
  • small intestine: 16 nTPM
  • colon: 15 nTPM

Single-cell type

  • rod photoreceptor cells: 995 nCPM
  • cone photoreceptor cells: 892 nCPM
  • microglia: 618 nCPM
  • loop of henle epithelial cells: 614 nCPM
  • ocular epithelial cells: 291 nCPM
  • t-cells: 258 nCPM

Immune cell

  • memory CD8 T-cell: 1.4 nTPM
  • memory CD4 T-cell: 1.3 nTPM
  • T-reg: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • NK-cell: 1 nTPM
  • naive CD8 T-cell: 0.9 nTPM

Brain region

  • hippocampal formation: 56 nTPM
  • cerebral cortex: 51 nTPM
  • thalamus: 26 nTPM
  • basal ganglia: 25 nTPM
  • cerebellum: 23 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.74
gnomAD missense Z
2.25
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC4A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC4A7 as an antibody target. Whether an autoantibody or antibody against SLC4A7 could matter depends on whether native SLC4A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC4A7 is annotated at the cell surface, where native SLC4A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC4A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC4A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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