Seroatlas · Human Serome Atlas

CYTIP

Cytohesin-interacting protein

Also known as: B3-1, CASP, CYBR, CYTHIP, CYTIP_HUMAN, HE, PSCDBP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60759
Gene
CYTIP
Ensembl
ENSG00000115165
Chromosome
2
Canonical length
359 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>O60759|CYTIP
     1  MSLQRLLQHS SNGNLADFCA GPAYSSYSTL TGSLTMDDNR RIQMLADTVA TLPRGRKQLA
    61  LTRSSSLSDF SWSQRKLVTV EKQDNETFGF EIQSYRPQNQ NACSSEMFTL ICKIQEDSPA
   121  HCAGLQAGDV LANINGVSTE GFTYKQVVDL IRSSGNLLTI ETLNGTMILK RTELEAKLQV
   181  LKQTLKQKWV EYRSLQLQEH RLLHGDAANC PSLENMDLDE LSLFGPLPGP GPALVDRNRL
   241  SSESSCKSWL SSMTMDSEDG YQTCVSEDSS RGAFSRQTST DDECFIPKEG DDFLRRSSSR
   301  RNRSISNTSS GSMSPLWEGN LSSMFGTLPR KSRKGSVRKQ LLKFIPGLHR AVEEEESRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CYTIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
107 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 107 nTPM
  • bone marrow: 100 nTPM
  • lymph node: 86 nTPM
  • appendix: 66 nTPM
  • thymus: 50 nTPM
  • spleen: 41 nTPM

Single-cell type

  • neutrophils: 1,793 nCPM
  • breast lactating cells: 658 nCPM
  • t-cells: 579 nCPM
  • plasma cells: 515 nCPM
  • cdc: 493 nCPM
  • nk-cells: 460 nCPM

Immune cell

  • basophil: 250 nTPM
  • non-classical monocyte: 249 nTPM
  • naive CD4 T-cell: 206 nTPM
  • neutrophil: 204 nTPM
  • naive CD8 T-cell: 162 nTPM
  • total PBMC: 155 nTPM

Brain region

  • cerebral cortex: 7.2 nTPM
  • choroid plexus: 7.2 nTPM
  • white matter: 5.7 nTPM
  • medulla oblongata: 5.5 nTPM
  • pons: 4.3 nTPM
  • spinal cord: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CYTIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CYTIP as an antibody target. Whether an autoantibody or antibody against CYTIP could matter depends on whether native CYTIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CYTIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CYTIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CYTIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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