Seroatlas · Human Serome Atlas

DPF1

Zinc finger protein neuro-d4

Also known as: BAF45b, DPF1_HUMAN, NEUD4, neuro-d4, SMARCG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92782
Gene: DPF1
Ensembl: ENSG00000011332
Chromosome: 19
Canonical length: 387 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in nervous system development. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of nBAF complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q92782|DPF1
     1  MATVIPGPLS LGEDFYREAI EHCRSYNARL CAERSLRLPF LDSQTGVAQN NCYIWMEKTH
    61  RGPGLAPGQI YTYPARCWRK KRRLNILEDP RLRPCEYKID CEAPLKKEGG LPEGPVLEAL
   121  LCAETGEKKI ELKEEETIMD CQKQQLLEFP HDLEVEDLED DIPRRKNRAK GKAYGIGGLR
   181  KRQDTASLED RDKPYVCDIC GKRYKNRPGL SYHYTHTHLA EEEGEENAER HALPFHRKNN
   241  HKQFYKELAW VPEAQRKHTA KKAPDGTVIP NGYCDFCLGG SKKTGCPEDL ISCADCGRSG
   301  HPSCLQFTVN MTAAVRTYRW QCIECKSCSL CGTSENDDQL LFCDDCDRGY HMYCLSPPMA
   361  EPPEGSWSCH LCLRHLKEKA SAYITLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 31 nTPM
basal ganglia: 22 nTPM
hippocampal formation: 19 nTPM
amygdala: 18 nTPM
hypothalamus: 12 nTPM
cerebellum: 9.6 nTPM

Single-cell type

late spermatids: 48 nCPM
early spermatids: 35 nCPM
oligodendrocyte progenitor cells: 32 nCPM
brain inhibitory neurons: 31 nCPM
retinal amacrine cells: 30 nCPM
retinal horizontal cells: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 50 nTPM
hippocampal formation: 43 nTPM
basal ganglia: 39 nTPM
white matter: 38 nTPM
amygdala: 30 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 3.07
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPF1 as an antibody target. Whether an autoantibody or antibody against DPF1 could matter depends on whether native DPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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