Seroatlas · Human Serome Atlas

SLC1A1

Excitatory amino acid transporter 3

Also known as: EAA3_HUMAN, EAAC1, EAAT3, hEAAC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43005
Gene
SLC1A1
Ensembl
ENSG00000106688
Chromosome
9
Canonical length
524 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>P43005|SLC1A1
     1  MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF YFAFPGEILM
    61  RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC TTLIAVILGI VLVVSIKPGV
   121  TQKVGEIART GSTPEVSTVD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PPSDPEMNMT
   181  EESFTAVMTT AISKNKTKEY KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF
   241  NALSDATMKI VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI
   301  LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV DKRITRFVLP
   361  VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT ATSASIGAAG VPQAGLVTMV
   421  IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN
   481  IVNPFALEST ILDNEDSDTK KSYVNGGFAV DKSDTISFTQ TSQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 61 nTPM
  • kidney: 48 nTPM
  • epididymis: 43 nTPM
  • liver: 39 nTPM
  • duodenum: 33 nTPM
  • thyroid gland: 28 nTPM

Single-cell type

  • proximal tubule cells: 418 nCPM
  • endometrial glandular cells: 409 nCPM
  • pituicytes/fscs: 398 nCPM
  • enterocytes: 358 nCPM
  • oligodendrocyte progenitor cells: 276 nCPM
  • alveolar cells type 1: 231 nCPM

Immune cell

  • T-reg: 0.6 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hippocampal formation: 36 nTPM
  • basal ganglia: 34 nTPM
  • cerebral cortex: 32 nTPM
  • thalamus: 32 nTPM
  • pons: 31 nTPM
  • amygdala: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC1A1.

Disease | AllUniProt

Conditions SLC1A1 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 249 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
-1.33
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC1A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC1A1 as an antibody target. Whether an autoantibody or antibody against SLC1A1 could matter depends on whether native SLC1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC1A1 is annotated at the cell surface, where native SLC1A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC1A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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