Dicarboxylate/Amino Acid:Cation Symporter
IPR050746
Definition
The dicarboxylate/amino acid:cation symporter family is involved in the sodium-dependent, high-affinity transport of amino acids such as L-glutamate, L- and D-aspartate, and L-cysteine across cell membranes. Members function as symporters, co-transporting amino acids with Na+ ions and a proton, while counter-transporting a K+ ion. They play crucial roles in rapidly clearing glutamate from synaptic clefts, terminating postsynaptic action, and contributing to glutathione biosynthesis and oxidative stress protection. Some members also mediate Cl- flux independent of amino acid transport and exhibit substrate-specific transport regulation.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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