Seroatlas · Human Serome Atlas

SLC1A3

Excitatory amino acid transporter 1

Also known as: EA6, EAA1_HUMAN, EAAT1, GLAST, GLAST-1, GLAST1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43003
Gene
SLC1A3
Ensembl
ENSG00000079215
Chromosome
5
Canonical length
542 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli,Vesicles
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>P43003|SLC1A3
     1  MTKSNGEEPK MGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF VLLTVTAVIV
    61  GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI ISSLVTGMAA LDSKASGKMG
   121  MRAVVYYMTT TIIAVVIGII IVIIIHPGKG TKENMHREGK IVRVTAADAF LDLIRNMFPP
   181  NLVEACFKQF KTNYEKRSFK VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG
   241  VNALGLVVFS MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK
   301  IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG GLLQALITAL
   361  GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD GTALYEALAA IFIAQVNNFE
   421  LNFGQIITIS ITATAASIGA AGIPQAGLVT MVIVLTSVGL PTDDITLIIA VDWFLDRLRT
   481  TTNVLGDSLG AGIVEHLSRH ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET
   541  KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC1A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
527 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 527 nTPM
  • amygdala: 472 nTPM
  • basal ganglia: 455 nTPM
  • hippocampal formation: 269 nTPM
  • cerebellum: 248 nTPM
  • midbrain: 219 nTPM

Single-cell type

  • bergmann glia: 5,598 nCPM
  • astrocytes: 2,442 nCPM
  • microglia: 1,557 nCPM
  • ependymal cells: 1,345 nCPM
  • pituicytes/fscs: 1,168 nCPM
  • müller glia: 1,040 nCPM

Immune cell

  • myeloid DC: 1.6 nTPM
  • classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.2 nTPM
  • total PBMC: 0.2 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 456 nTPM
  • cerebellum: 381 nTPM
  • basal ganglia: 370 nTPM
  • thalamus: 350 nTPM
  • midbrain: 304 nTPM
  • medulla oblongata: 290 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC1A3.

Disease | AllUniProt

Conditions SLC1A3 is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 334 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Episodic ataxia type 6

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
1.79
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC1A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC1A3 as an antibody target. Whether an autoantibody or antibody against SLC1A3 could matter depends on whether native SLC1A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC1A3 is annotated at the cell surface, where native SLC1A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC1A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC1A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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