FAM210A
Protein FAM210A
Also known as: C18orf19, F210A_HUMAN, HsT2329, MGC24180
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96ND0
- Gene
- FAM210A
- Ensembl
- ENSG00000177150
- Chromosome
- 18
- Canonical length
- 272 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus,Mitochondria
OverviewNCBI Gene
Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
272 residues, UniProt reviewed canonical sequence.
>Q96ND0|FAM210A
1 MQWNVPRTVS RLARRTCLEP HNAGLFGHCQ NVKGPLLLYN AESKVVLVQG PQKQWLHLSA
61 AQCVAKERRP LDAHPPQPGV LRHKQGKQHV SFRRVFSSSA TAQGTPEKKE EPDPLQDKSI
121 SLYQRFKKTF RQYGKVLIPV HLITSGVWFG TFYYAALKGV NVVPFLELIG LPDSVVSILK
181 NSQSGNALTA YALFKIATPA RYTVTLGGTS VTVKYLRSHG YMSTPPPVKE YLQDRMEETK
241 ELITEKMEET KDRLTEKLQE TKEKVSFKKK VELocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM210A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- tongue: 31 nTPM
- skeletal muscle: 24 nTPM
- heart muscle: 20 nTPM
- liver: 12 nTPM
- retina: 11 nTPM
- duodenum: 8.8 nTPM
Single-cell type
- esophageal apical cells: 171 nCPM
- endometrial luminal cells: 88 nCPM
- cdc: 80 nCPM
- choroid plexus epithelial cells: 79 nCPM
- retinal bipolar cells: 79 nCPM
- endometrial glandular cells: 69 nCPM
Immune cell
- intermediate monocyte: 7.9 nTPM
- MAIT T-cell: 6.7 nTPM
- myeloid DC: 6.4 nTPM
- naive CD4 T-cell: 6.4 nTPM
- gdT-cell: 6.2 nTPM
- naive B-cell: 6.2 nTPM
Brain region
- choroid plexus: 21 nTPM
- cerebral cortex: 20 nTPM
- midbrain: 19 nTPM
- thalamus: 18 nTPM
- white matter: 17 nTPM
- cerebellum: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.46
- DepMap mean gene effect
- -0.42
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM210A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM210A as an antibody target. Whether an autoantibody or antibody against FAM210A could matter depends on whether native FAM210A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM210A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM210A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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