Seroatlas · Human Serome Atlas

NUMBL

Numb-like protein

Also known as: CAG3A, CTG3a, NUMB-R, NUMBL_HUMAN, NUMBLIKE, NUMBR, TNRC23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6R0
Gene
NUMBL
Ensembl
ENSG00000105245
Chromosome
19
Canonical length
609 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Involved in cytokine-mediated signaling pathway. Predicted to be active in cytoplasm and glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

609 residues, UniProt reviewed canonical sequence.

>Q9Y6R0|NUMBL
     1  MSRSAAASGG PRRPERHLPP APCGAPGPPE TCRTEPDGAG TMNKLRQSLR RRKPAYVPEA
    61  SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE DAVKKLKAMG RKSVKSVLWV
   121  SADGLRVVDD KTKDLLVDQT IEKVSFCAPD RNLDKAFSYI CRDGTTRRWI CHCFLALKDS
   181  GERLSHAVGC AFAACLERKQ RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAPD
   241  KKKAEAAAAP TVAPGPAQPG HVSPTPATTS PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL
   301  VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL PSTLQRRTDF QVKGTVPEME PPGAGDSDSI
   361  NALCTQISSS FASAGAPAPG PPPATTGTSA WGEPSVPPAA AFQPGHKRTP SEAERWLEEV
   421  SQVAKAQQQQ QQQQQQQQQQ QQQQQQAASV APVPTMPPAL QPFPAPVGPF DAAPAQVAVF
   481  LPPPHMQPPF VPAYPGLGYP PMPRVPVVGI TPSQMVANAF CSAAQLQPQP ATLLGKAGAF
   541  PPPAIPSAPG SQARPRPNGA PWPPEPAPAP APELDPFEAQ WAALEGKATV EKPSNPFSGD
   601  LQKTFEIEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUMBL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 67 nTPM
  • blood vessel: 48 nTPM
  • cerebellum: 44 nTPM
  • cervix: 42 nTPM
  • endometrium: 42 nTPM
  • cerebral cortex: 41 nTPM

Single-cell type

  • leydig cells: 61 nCPM
  • peritubular myoid cells: 55 nCPM
  • ocular epithelial cells: 42 nCPM
  • epicardial cells: 41 nCPM
  • fibro-adipogenic progenitors: 40 nCPM
  • pituicytes/fscs: 38 nCPM

Immune cell

  • gdT-cell: 1.1 nTPM
  • non-classical monocyte: 0.8 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • neutrophil: 0.2 nTPM

Brain region

  • cerebral cortex: 100 nTPM
  • hippocampal formation: 98 nTPM
  • basal ganglia: 93 nTPM
  • amygdala: 87 nTPM
  • cerebellum: 75 nTPM
  • hypothalamus: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
3.03
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUMBL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUMBL as an antibody target. Whether an autoantibody or antibody against NUMBL could matter depends on whether native NUMBL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUMBL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUMBL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUMBL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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