Seroatlas · Human Serome Atlas

SORCS2

VPS10 domain-containing receptor SorCS2

Also known as: KIAA1329, SORC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PQ0
Gene
SORCS2
Ensembl
ENSG00000184985
Chromosome
4
Canonical length
1159 aa
Protein class
Plasma proteins, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1159 residues, UniProt reviewed canonical sequence.

>Q96PQ0|SORCS2
     1  MAHRGPSRAS KGPGPTARAP SPGAPPPPRS PRSRPLLLLL LLLGACGAAG RSPEPGRLGP
    61  HAQLTRVPRS PPAGRAEPGG GEDRQARGTE PGAPGPSPGP APGPGEDGAP AAGYRRWERA
   121  APLAGVASRA QVSLISTSFV LKGDATHNQA MVHWTGENSS VILILTKYYH ADMGKVLESS
   181  LWRSSDFGTS YTKLTLQPGV TTVIDNFYIC PTNKRKVILV SSSLSDRDQS LFLSADEGAT
   241  FQKQPIPFFV ETLIFHPKEE DKVLAYTKES KLYVSSDLGK KWTLLQERVT KDHVFWSVSG
   301  VDADPDLVHV EAQDLGGDFR YVTCAIHNCS EKMLTAPFAG PIDHGSLTVQ DDYIFFKATS
   361  ANQTKYYVSY RRNEFVLMKL PKYALPKDLQ IISTDESQVF VAVQEWYQMD TYNLYQSDPR
   421  GVRYALVLQD VRSSRQAEES VLIDILEVRG VKGVFLANQK IDGKVMTLIT YNKGRDWDYL
   481  RPPSMDMNGK PTNCKPPDCH LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY
   541  KEEMYITSDC GHTWRQVFEE EHHILYLDHG GVIVAIKDTS IPLKILKFSV DEGLTWSTHN
   601  FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFSRQCG EEDYSSWELS
   661  NLQGDRCIMG QQRSFRKRKS TSWCIKGRSF TSALTSRVCE CRDSDFLCDY GFERSSSSES
   721  STNKCSANFW FNPLSPPDDC ALGQTYTSSL GYRKVVSNVC EGGVDMQQSQ VQLQCPLTPP
   781  RGLQVSIQGE AVAVRPGEDV LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH
   841  RYESPGIYRV SVRAENTAGH DEAVLFVQVN SPLQALYLEV VPVIGLNQEV NLTAVLLPLN
   901  PNLTVFYWWI GHSLQPLLSL DNSVTTRFSD TGDVRVTVQA ACGNSVLQDS RVLRVLDQFQ
   961  VMPLQFSKEL DAYNPNTPEW REDVGLVVTR LLSKETSVPQ ELLVTVVKPG LPTLADLYVL
  1021  LPPPRPTRKR SLSSDKRLAA IQQVLNAQKI SFLLRGGVRV LVALRDTGTG AEQLGGGGGY
  1081  WAVVVLFVIG LFAAGAFILY KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDVQGAVQGN
  1141  HSGVVLSINS REMHSYLVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SORCS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 17 nTPM
  • cerebral cortex: 15 nTPM
  • amygdala: 13 nTPM
  • retina: 12 nTPM
  • spinal cord: 11 nTPM
  • hippocampal formation: 11 nTPM

Single-cell type

  • retinal bipolar cells: 518 nCPM
  • astrocytes: 211 nCPM
  • müller glia: 203 nCPM
  • bergmann glia: 184 nCPM
  • thyrotrophs: 167 nCPM
  • retinal amacrine cells: 157 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 56 nTPM
  • medulla oblongata: 49 nTPM
  • midbrain: 48 nTPM
  • basal ganglia: 48 nTPM
  • cerebral cortex: 41 nTPM
  • pons: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SORCS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SORCS2 as an antibody target. Whether an autoantibody or antibody against SORCS2 could matter depends on whether native SORCS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SORCS2 is annotated at the cell surface, where native SORCS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SORCS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SORCS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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