Seroatlas · Human Serome Atlas

TMEM9B

Transmembrane protein 9B

Also known as: C11orf15, TMM9B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQ34
Gene: TMEM9B
Ensembl: ENSG00000175348
Chromosome: 11
Canonical length: 198 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Involved in positive regulation of canonical NF-kappaB signal transduction. Located in early endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9NQ34|TMEM9B
     1  MATLWGGLLR LGSLLSLSCL ALSVLLLAQL SDAAKNFEDV RCKCICPPYK ENSGHIYNKN
    61  ISQKDCDCLH VVEPMPVRGP DVEAYCLRCE CKYEERSSVT IKVTIIIYLS ILGLLLLYMV
   121  YLTLVEPILK RRLFGHAQLI QSDDDIGDHQ PFANAHDVLA RSRSRANVLN KVEYAQQRWK
   181  LQVQEQRKSV FDRHVVLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 74 nTPM
thyroid gland: 70 nTPM
spinal cord: 65 nTPM
midbrain: 63 nTPM
rectum: 63 nTPM
basal ganglia: 60 nTPM

Single-cell type

esophageal apical cells: 387 nCPM
esophageal suprabasal cells: 236 nCPM
syncytiotrophoblasts: 207 nCPM
oocytes: 170 nCPM
extravillous trophoblasts: 154 nCPM
parietal cells: 150 nCPM

Immune cell

basophil: 179 nTPM
total PBMC: 160 nTPM
eosinophil: 152 nTPM
non-classical monocyte: 151 nTPM
T-reg: 137 nTPM
intermediate monocyte: 135 nTPM

Brain region

white matter: 71 nTPM
thalamus: 67 nTPM
medulla oblongata: 64 nTPM
spinal cord: 63 nTPM
cerebellum: 61 nTPM
basal ganglia: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.53
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of canonical NF-kappaB signal transduction

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM9B as an antibody target. Whether an autoantibody or antibody against TMEM9B could matter depends on whether native TMEM9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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