Seroatlas · Human Serome Atlas

AGPAT2

1-acyl-sn-glycerol-3-phosphate acyltransferase beta

Also known as: BSCL, LPAAT-beta, LPLAT2, PLCB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15120
Gene
AGPAT2
Ensembl
ENSG00000169692
Chromosome
9
Canonical length
278 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>O15120|AGPAT2
     1  MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM
    61  SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK
   121  RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENLKVWIY PEGTRNDNGD
   181  LLPFKKGAFY LAVQAQVPIV PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD
   241  VPALVDTCHR AMRTTFLHIS KTPQENGATA GSGVQPAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGPAT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
427 nTPM

Expression across tissuesHPA

Tissue

  • liver: 427 nTPM
  • adipose tissue: 349 nTPM
  • breast: 251 nTPM
  • pancreas: 124 nTPM
  • small intestine: 113 nTPM
  • duodenum: 105 nTPM

Single-cell type

  • enterocytes: 1,291 nCPM
  • esophageal apical cells: 1,017 nCPM
  • colonocytes: 620 nCPM
  • late spermatids: 596 nCPM
  • alveolar cells type 2: 271 nCPM
  • hepatocytes: 262 nCPM

Immune cell

  • eosinophil: 112 nTPM
  • classical monocyte: 89 nTPM
  • intermediate monocyte: 84 nTPM
  • non-classical monocyte: 76 nTPM
  • plasmacytoid DC: 66 nTPM
  • neutrophil: 61 nTPM

Brain region

  • hypothalamus: 19 nTPM
  • choroid plexus: 19 nTPM
  • midbrain: 16 nTPM
  • thalamus: 15 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGPAT2.

Disease | AllUniProt

Conditions AGPAT2 is implicated in, by any mechanism.

  • Lipodystrophy, congenital generalized, 1 (CGL1) MIM:608594

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 295 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.54
gnomAD pLI
0
gnomAD missense Z
-0.72
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGPAT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGPAT2 as an antibody target. Whether an autoantibody or antibody against AGPAT2 could matter depends on whether native AGPAT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGPAT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGPAT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGPAT2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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