Sec23/Sec24, trunk domain

Definition

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex PMID:11535824. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation PMID:12239560. Sec23 p and Sec24p are structurally related, folding into five distinct domains: a β-barrel, a zinc-finger ([interpro:IPR006895]), an α/β trunk domain, an all-helical region ([interpro:IPR006900]), and a C-terminal gelsolin-like domain ([interpro:IPR007123]). This entry describes the Sec23/24 α/β trunk domain, which is formed from a single, approximately 250-residue segment plugged into the β-barrel between strands β1 and β19. The trunk has an α/β fold with a vWA topology, and it forms the dimer interface, primarily involving strand β14 on Sec23 and Sec24; in addition, the trunk domain of Sec23 contacts Sar1.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• SEC23A
• SEC23B
• SEC24A
• SEC24B
• SEC24C
• SEC24D