Sec23/Sec24 helical domain superfamily

Definition

COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex PMID:11535824. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation PMID:12239560. Sec23 p and Sec24p are structurally related, folding into five distinct domains: a β-barrel, a zinc-finger ([interpro:IPR006895]), an α/β trunk domain ([interpro:IPR006896]), an all-helical region, and a C-terminal gelsolin-like domain ([interpro:IPR007123]). This entry describes the all-helical domain, which forms an approximately 105-residue segment with the C-terminal 30 residues. The linker between alpha-M and alpha-N contacts Sar1.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• SEC23A
• SEC23B
• SEC24A
• SEC24B
• SEC24C
• SEC24D