Seroatlas · Human Serome Atlas

TMEM39A

Transmembrane protein 39A

Also known as: FLJ10902, SUSR2, TM39A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV64
Gene: TMEM39A
Ensembl: ENSG00000176142
Chromosome: 3
Canonical length: 488 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9NV64|TMEM39A
     1  MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI TALITPGPVR
    61  HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW YPYNHPASCT SLNFHLIDYH
   121  LAAFITVMLA RRLVWALISE ATKAGAASMI HYMVLISARL VLLTLCGWVL CWTLVNLFRS
   181  HSVLNLLFLG YPFGVYVPLC CFHQDSRAHL LLTDYNYVVQ HEAVEESAST VGGLAKSKDF
   241  LSLLLESLKE QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
   301  FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA AHLGKWQKLE
   361  HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAMGPYNVA VPSDVSHARF YFLFHRPLRL
   421  LNLLILIEGS VVFYQLYSLL RSEKWNHTLS MALILFCNYY VLFKLLRDRI VLGRAYSYPL
   481  NSYELKAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM39A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

pancreas: 27 nTPM
cervix: 18 nTPM
placenta: 17 nTPM
thyroid gland: 16 nTPM
appendix: 14 nTPM
ovary: 14 nTPM

Single-cell type

monocyte progenitors: 140 nCPM
pdcs: 109 nCPM
plasma cells: 103 nCPM
cardiomyocytes: 98 nCPM
cdc: 97 nCPM
extravillous trophoblasts: 92 nCPM

Immune cell

plasmacytoid DC: 17 nTPM
basophil: 13 nTPM
myeloid DC: 12 nTPM
NK-cell: 12 nTPM
MAIT T-cell: 12 nTPM
gdT-cell: 12 nTPM

Brain region

choroid plexus: 28 nTPM
white matter: 17 nTPM
thalamus: 15 nTPM
medulla oblongata: 14 nTPM
basal ganglia: 14 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 1.55
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM39A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM39A as an antibody target. Whether an autoantibody or antibody against TMEM39A could matter depends on whether native TMEM39A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM39A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM39A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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