Seroatlas · Human Serome Atlas

PRRC1

Protein PRRC1

Also known as: FLJ32875, PRRC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96M27
Gene
PRRC1
Ensembl
ENSG00000164244
Chromosome
5
Canonical length
445 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in epithelial structure maintenance. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q96M27|PRRC1
     1  MMEESGIETT PPGTPPPNPA GLAATAMSST PVPLAATSSF SSPNVSSMES FPPLAYSTPQ
    61  PPLPPVRPSA PLPFVPPPAV PSVPPLVTSM PPPVSPSTAA AFGNPPVSHF PPSTSAPNTL
   121  LPAPPSGPPI SGFSVGSTYD ITRGHAGRAP QTPLMPSFSA PSGTGLLPTP ITQQASLTSL
   181  AQGTGTTSAI TFPEEQEDPR ITRGQDEASA GGIWGFIKGV AGNPMVKSVL DKTKHSVESM
   241  ITTLDPGMAP YIKSGGELDI VVTSNKEVKV AAVRDAFQEV FGLAVVVGEA GQSNIAPQPV
   301  GYAAGLKGAQ ERIDSLRRTG VIHEKQTAVS VENFIAELLP DKWFDIGCLV VEDPVHGIHL
   361  ETFTQATPVP LEFVQQAQSL TPQDYNLRWS GLLVTVGEVL EKSLLNVSRT DWHMAFTGMS
   421  RRQMIYSAAR AIAGMYKQRL PPRTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 30 nTPM
  • parathyroid gland: 29 nTPM
  • cervix: 26 nTPM
  • rectum: 26 nTPM
  • placenta: 25 nTPM
  • liver: 25 nTPM

Single-cell type

  • lactotrophs: 99 nCPM
  • somatotrophs: 98 nCPM
  • corticotrophs: 75 nCPM
  • extravillous trophoblasts: 69 nCPM
  • pancreatic acinar cells: 69 nCPM
  • gonadotrophs: 64 nCPM

Immune cell

  • MAIT T-cell: 23 nTPM
  • gdT-cell: 19 nTPM
  • basophil: 19 nTPM
  • naive CD4 T-cell: 17 nTPM
  • memory CD8 T-cell: 16 nTPM
  • myeloid DC: 16 nTPM

Brain region

  • choroid plexus: 25 nTPM
  • white matter: 19 nTPM
  • medulla oblongata: 16 nTPM
  • cerebellum: 16 nTPM
  • midbrain: 15 nTPM
  • basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRC1 as an antibody target. Whether an autoantibody or antibody against PRRC1 could matter depends on whether native PRRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRRC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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