Seroatlas · Human Serome Atlas

RSL1D1

Ribosomal L1 domain-containing protein 1

Also known as: CSIG, DKFZP564M182, L12, PBK1, RL1D1_HUMAN, UTP30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76021
Gene: RSL1D1
Ensembl: ENSG00000171490
Chromosome: 16
Canonical length: 490 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoli rim,Mitotic chromosome,Vesicles,Primary cilium

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located in several cellular components, including cilium; cytosol; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>O76021|RSL1D1
     1  MEDSASASLS SAAATGTSTS TPAAPTARKQ LDKEQVRKAV DALLTHCKSR KNNYGLLLNE
    61  NESLFLMVVL WKIPSKELRV RLTLPHSIRS DSEDICLFTK DEPNSTPEKT EQFYRKLLNK
   121  HGIKTVSQII SLQTLKKEYK SYEAKLRLLS SFDFFLTDAR IRRLLPSLIG RHFYQRKKVP
   181  VSVNLLSKNL SREINDCIGG TVLNISKSGS CSAIRIGHVG MQIEHIIENI VAVTKGLSEK
   241  LPEKWESVKL LFVKTEKSAA LPIFSSFVSN WDEATKRSLL NKKKKEARRK RRERNFEKQK
   301  ERKKKRQQAR KTASVLSKDD VAPESGDTTV KKPESKKEQT PEHGKKKRGR GKAQVKATNE
   361  SEDEIPQLVP IGKKTPANEK VEIQKHATGK KSPAKSPNPS TPRGKKRKAL PASETPKAAE
   421  SETPGKSPEK KPKIKEEAVK EKSPSLGKKD ARQTPKKPEA KFFTTPSKSV RKASHTPKKW
   481  PKKPKVPQST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSL1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 93 nTPM

Expression across tissuesHPA

Tissue

ovary: 93 nTPM
skeletal muscle: 80 nTPM
breast: 74 nTPM
tonsil: 61 nTPM
tongue: 48 nTPM
lymph node: 45 nTPM

Single-cell type

esophageal basal cells: 362 nCPM
decidual stromal cells: 360 nCPM
migrating cytotrophoblasts: 348 nCPM
oocytes: 345 nCPM
extravillous trophoblasts: 331 nCPM
ovarian stromal cells: 321 nCPM

Immune cell

total PBMC: 252 nTPM
naive CD4 T-cell: 186 nTPM
naive CD8 T-cell: 137 nTPM
memory B-cell: 133 nTPM
myeloid DC: 131 nTPM
memory CD4 T-cell: 130 nTPM

Brain region

white matter: 32 nTPM
cerebral cortex: 29 nTPM
spinal cord: 28 nTPM
cerebellum: 28 nTPM
hypothalamus: 28 nTPM
choroid plexus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -1.61
DepMap mean gene effect: -1.39
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSL1D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSL1D1 as an antibody target. Whether an autoantibody or antibody against RSL1D1 could matter depends on whether native RSL1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSL1D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSL1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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