KPNA7

Protein identityUniProt · HPA

UniProt accession

A9QM74

Gene

KPNA7

Ensembl

ENSG00000185467

Chromosome

7

Canonical length

516 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import, but exhibits different nuclear localization signal binding specificity compared to other members of the family. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

516 residues, UniProt reviewed canonical sequence.

>A9QM74|KPNA7
     1  MPTLDAPEER RRKFKYRGKD VSLRRQQRMA VSLELRKAKK DEQTLKRRNI TSFCPDTPSE
    61  KTAKGVAVSL TLGEIIKGVN SSDPVLCFQA TQTARKMLSQ EKNPPLKLVI EAGLIPRMVE
   121  FLKSSLYPCL QFEAAWALTN IASGTSEQTR AVVEGGAIQP LIELLSSSNV AVCEQAVWAL
   181  GNIAGDGPEF RDNVITSNAI PHLLALISPT LPITFLRNIT WTLSNLCRNK NPYPCDTAVK
   241  QILPALLHLL QHQDSEVLSD ACWALSYLTD GSNKRIGQVV NTGVLPRLVV LMTSSELNVL
   301  TPSLRTVGNI VTGTDEQTQM AIDAGMLNVL PQLLQHNKPS IQKEAAWALS NVAAGPCHHI
   361  QQLLAYDVLP PLVALLKNGE FKVQKEAVWM VANFATGATM DQLIQLVHSG VLEPLVNLLT
   421  APDVKIVLII LDVISCILQA AEKRSEKENL CLLIEELGGI DRIEALQLHE NRQIGQSALN
   481  IIEKHFGEEE DESQTLLSQV IDQDYEFIDY ECLAKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KPNA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

3.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KPNA7.

Disease | AllUniProt

Conditions KPNA7 is implicated in, by any mechanism.

• Oocyte/zygote/embryo maturation arrest 17 (OZEMA17) MIM:620319

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 546 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Oocyte/zygote/embryo maturation arrest 17

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0

gnomAD missense Z

0.91

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blastocyst development
• epigenetic regulation of gene expression
• negative regulation of gene expression
• NLS-bearing protein import into nucleus
• positive regulation of gene expression
• protein import into nucleus

Molecular functions

• nuclear import signal receptor activity
• nuclear localization sequence binding

Cellular components

• cytosol
• female germ cell nucleus
• NLS-dependent protein nuclear import complex
• nucleoplasm
• nucleus
• spindle

Protein domainsUniProt · Pfam · InterPro

• Armadillo
• Importin-alpha, importin-beta-binding domain
• Armadillo-like helical
• Armadillo-type fold
• Importin subunit alpha
• Atypical Arm repeat
• Importin-alpha, importin-beta-binding domain superfamily
• Armadillo/beta-catenin-like repeat
• Importin beta binding domain
• Atypical Arm repeat

KeywordsUniProt

• Nucleus
• Protein transport
• Repeat
• Transport

InteractionsUniProt · HPA

Protein binding partners of KPNA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RSL1D1
• KPNB1