NUDT3

Protein identityUniProt · HPA

UniProt accession

O95989

Gene

NUDT3

Ensembl

ENSG00000272325

Chromosome

6

Canonical length

172 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>O95989|NUDT3
     1  MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS
    61  VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF
   121  KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

66 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.66

gnomAD pLI

0.43

gnomAD missense Z

1.32

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
• cell-cell signaling
• diadenosine hexaphosphate catabolic process
• diadenosine pentaphosphate catabolic process
• diphosphoinositol polyphosphate metabolic process
• RNA decapping
• diadenosine polyphosphate catabolic process
• diphosphoinositol polyphosphate catabolic process

Molecular functions

• 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
• 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
• bis(5'-adenosyl)-hexaphosphatase activity
• bis(5'-adenosyl)-pentaphosphatase activity
• diphosphoinositol-polyphosphate diphosphatase activity
• endopolyphosphatase activity
• inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
• inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
• magnesium ion binding
• manganese ion binding
• zinc ion binding
• inositol diphosphate pentakisphosphate diphosphatase activity
• inositol diphosphate tetrakisphosphate diphosphatase activity

Cellular components

• cytoplasm
• cytosol
• glutamatergic synapse
• nucleus

Protein domainsUniProt · Pfam · InterPro

• NUDIX hydrolase domain
• NUDIX hydrolase-like domain superfamily
• NUDIX hydrolase, conserved site
• Diphosphoinositol polyphosphate phosphohydrolase-like, NUDIX domain
• NUDIX domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Hydrolase
• Magnesium
• Manganese
• Metal-binding
• Nucleus
• Zinc

InteractionsUniProt · HPA

Protein binding partners of NUDT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ASB13
• RPLP1