Transcriptional Regulator and Corepressor
IPR051066
Definition
This family of proteins includes transcriptional regulators and corepressors that are involved in the modulation of gene expression through chromatin remodeling. Members of this family are known to bind DNA and activate or repress transcription of specific target genes. They are involved in various biological processes, such as steroid biosynthesis, neuron-specific gene repression in non-neuronal cells, and the progression of meiosis in spermatocytes. Some proteins in this family function by interacting with other proteins to form complexes that modify histones through deacetylation and demethylation, thereby influencing chromatin structure and gene expression. They play roles in developmental processes, fertility, and hematopoietic differentiation.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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